INT265663

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT)
plasma membrane (COMT) cytoplasm (COMT)
COMT (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 220 100.00 Very High Very High Very High
IPN 6 6.88 Low Low
Pain 41 5.00 Very Low Very Low Very Low
Catecholamine 10 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Astrocytoma 8 97.76 Very High Very High Very High
Hantavirus Infection 78 83.16 Quite High
Inflammatory Pain 6 6.88 Low Low
Pain 41 5.00 Very Low Very Low Very Low
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Cognitive Disorder 7 5.00 Very Low Very Low Very Low
Schizophrenia 6 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Temporomandibular Joint Disorders 5 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transient transfection of COMT cDNA clones
Positive_regulation (transfection) of Gene_expression (transfection) of COMT associated with catechol-o-methyltransferase
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.16 Pain Relevance 0.16
Consistent with the observed down-regulation of endogenous COMT expression, TNF?
Positive_regulation (endogenous) of Gene_expression (expression) of COMT associated with catechol-o-methyltransferase
2) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.10 Pain Relevance 0.63

General Comments

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