INT265695

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.50 Pain Relevance 0.04

signal transduction (Lrba) Golgi apparatus (Lrba) endoplasmic reticulum (Lrba) cytoplasmic membrane-bounded vesicle (Lrba) plasma membrane (Lrba) lysosome (Lrba)

Lrba (Mus musculus)

Pain Link Frequency Relevance Heat depression 18 85.32 Eae 6 5.00 Neuropeptide 2 5.00 anesthesia 1 5.00 amygdala 1 5.00 neuropeptide release 1 5.00 Hippocampus 1 5.00 isoflurane 1 5.00 Potency 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 84 99.54 Depression 18 85.32 Diabetes Insipidus 3 5.00 Sprains And Strains 2 5.00 Heart Rate Under Development 2 5.00 Genetic Predisposition To Disease 2 5.00 Hypersensitivity 2 5.00 Agoraphobia 1 5.00 Overdose 1 5.00 Stress Incontinence 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this study, microarray analysis, in situ hybridization, quantitative real-time PCR and immunohistochemistry revealed decreased expression of the vasopressin gene (Avp) in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei of adult LAB mice compared to HAB, NAB (normal anxiety-related behavior) and HABxLAB F1 intercross controls, without detecting differences in receptor expression or density.

Regulation (controls) of HABxLAB associated with anxiety disorder

1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2663030 Disease Relevance 0.50 Pain Relevance 0.04

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