INT265730

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (AR, VEGFA) nucleoplasm (AR) transport (AR)
enzyme binding (AR) DNA binding (AR) cell-cell signaling (AR)
AR (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Restless leg syndrome 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 36 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Coronary Artery Disease 12 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Atherosclerosis 8 5.00 Very Low Very Low Very Low
Diabetes Mellitus 8 5.00 Very Low Very Low Very Low
Eclampsia 6 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, against general consensus that VEGF121 does not bind NRP1, Pan et al. recently observed such binding at Kd?
Kd Neg (not) Binding (bind) of VEGF121
1) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
We thus tested both scenarios: adding a new interaction between VEGF121 and NRP1 at a dissociation constant 1.83 times higher than our control Kd for VEGF165 and NRP1 (to match the Kd ratio measured by Pan et al.); and setting NRP1 affinities for both VEGF isoforms to the exact values as Pan et al. reported.
Kd Binding (interaction) of VEGF121
2) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0

General Comments

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