INT265737

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (AR, NRP1) signal transduction (AR, NRP1) cell differentiation (NRP1)
nucleoplasm (AR) transport (AR) DNA binding (AR)
AR (Homo sapiens)
NRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 21 5.00 Very Low Very Low Very Low
metalloproteinase 21 5.00 Very Low Very Low Very Low
antagonist 21 5.00 Very Low Very Low Very Low
ischemia 14 5.00 Very Low Very Low Very Low
Restless leg syndrome 7 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 126 5.00 Very Low Very Low Very Low
Disease 49 5.00 Very Low Very Low Very Low
Coronary Artery Disease 42 5.00 Very Low Very Low Very Low
Cancer 35 5.00 Very Low Very Low Very Low
Atherosclerosis 28 5.00 Very Low Very Low Very Low
Diabetes Mellitus 28 5.00 Very Low Very Low Very Low
Eclampsia 21 5.00 Very Low Very Low Very Low
Breast Cancer 14 5.00 Very Low Very Low Very Low
Leukemia 14 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lowering NRP1's affinity for VEGF165 over two orders of magnitude – Kd(V165,N) from 200 pM to 25 nM –caused only opposing changes of up to 0.3% in the VEGF-bound fractional occupancies of VEGFR1 and VEGFR2 (Fig. 6D).
Kd Binding (affinity) of VEGF165
1) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
In fact, against general consensus that VEGF121 does not bind NRP1, Pan et al. recently observed such binding at Kd?
Kd Neg (not) Binding (bind) of NRP1
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Lowering NRP1's affinity for VEGF165 over two orders of magnitude – Kd(V165,N) from 200 pM to 25 nM –caused only opposing changes of up to 0.3% in the VEGF-bound fractional occupancies of VEGFR1 and VEGFR2 (Fig. 6D).
Kd Binding (affinity) of NRP1's
3) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
VEGF165 affinity of NRP1s additionally varied with assay type: Kd?
Kd Binding (affinity) of NRP1s
4) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
We thus tested both scenarios: adding a new interaction between VEGF121 and NRP1 at a dissociation constant 1.83 times higher than our control Kd for VEGF165 and NRP1 (to match the Kd ratio measured by Pan et al.); and setting NRP1 affinities for both VEGF isoforms to the exact values as Pan et al. reported.
Kd Binding (interaction) of NRP1
5) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
We thus tested both scenarios: adding a new interaction between VEGF121 and NRP1 at a dissociation constant 1.83 times higher than our control Kd for VEGF165 and NRP1 (to match the Kd ratio measured by Pan et al.); and setting NRP1 affinities for both VEGF isoforms to the exact values as Pan et al. reported.
Kd Binding (interaction) of NRP1
6) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
VEGF165 affinity of NRP1s additionally varied with assay type: Kd?
Kd Binding (affinity) of VEGF165
7) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0

General Comments

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