INT265749

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FLT1, NRP1) extracellular region (FLT1, NRP1) plasma membrane (FLT1, NRP1)
endosome (FLT1) Golgi apparatus (FLT1) cell-cell signaling (NRP1)
Anatomy Link Frequency
blood 1
FLT1 (Homo sapiens)
NRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 24 78.16 Quite High
metalloproteinase 24 5.00 Very Low Very Low Very Low
antagonist 24 5.00 Very Low Very Low Very Low
ischemia 16 5.00 Very Low Very Low Very Low
Restless leg syndrome 8 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 144 5.00 Very Low Very Low Very Low
Disease 56 5.00 Very Low Very Low Very Low
Coronary Artery Disease 48 5.00 Very Low Very Low Very Low
Cancer 40 5.00 Very Low Very Low Very Low
Atherosclerosis 32 5.00 Very Low Very Low Very Low
Diabetes Mellitus 32 5.00 Very Low Very Low Very Low
Eclampsia 24 5.00 Very Low Very Low Very Low
Breast Cancer 16 5.00 Very Low Very Low Very Low
Leukemia 16 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overall drop in “anti-angiogenic potential”, as represented by ligated VEGFR1 complexes, can be explained by NRP1's high affinity for VEGFR1.
VEGFR1 Binding (affinity) of NRP1's
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
In the blood, both VEGF121 and VEGF165 were 23% free and 77% bound to sVEGFR1 (Fig.
sVEGFR1 Binding (bound) of VEGF165 in blood
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Higher NRP1 densities were generally associated with lower concentrations of all soluble species, since NRP1 was a vehicle for internalizing VEGF and sVEGFR1 via endothelial VEGF121-NRP1, VEGF165-NRP1, sVEGFR1-NRP1, VEGF121-VEGFR1-NRP1 complexes.
VEGFR1-NRP1 Binding (complexes) of NRP1
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Higher NRP1 densities were generally associated with lower concentrations of all soluble species, since NRP1 was a vehicle for internalizing VEGF and sVEGFR1 via endothelial VEGF121-NRP1, VEGF165-NRP1, sVEGFR1-NRP1, VEGF121-VEGFR1-NRP1 complexes.
VEGFR1-NRP1 Binding (complexes) of NRP1
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
The latter effects stemmed from an increasing proportion of total NRP1 being used up in formation of unligated VEGFR1-NRP1 complexes with increasing total VEGFR density (Fig. 5E).
VEGFR1-NRP1 Binding (complexes) of NRP1
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0.04
Regarding the new sVEGFR1 interactions with VEGF, matrix sites and NRP1, the following assumptions were made for their kinetic rates.
sVEGFR1 Binding (interactions) of NRP1
6) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
The directional change in free sVEGFR1 thus followed that of VEGFR2-VEGF165-NRP1 complexes (Fig. 6A) – i.e., the more VEGFR2-VEGF165-NRP1 complexes formed, the less unbound NRP1 available for binding and internalization of free sVEGFR1 (Fig. 6C).

4.2.

sVEGFR1 Binding (binding) of NRP1
7) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Higher NRP1 densities were generally associated with lower concentrations of all soluble species, since NRP1 was a vehicle for internalizing VEGF and sVEGFR1 via endothelial VEGF121-NRP1, VEGF165-NRP1, sVEGFR1-NRP1, VEGF121-VEGFR1-NRP1 complexes.
sVEGFR1 Binding (internalizing) of NRP1
8) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox