INT26575

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.11
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ubqln1) nucleus (Ubqln1) protein complex (Ubqln1)
cytoplasm (Ubqln1)
Anatomy Link Frequency
5-HT neurons 1
hippocampus 1
Ubqln1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 604 100.00 Very High Very High Very High
Endogenous opioid 2 99.80 Very High Very High Very High
gABA 9 99.32 Very High Very High Very High
Hippocampus 24 98.88 Very High Very High Very High
antidepressant 68 95.76 Very High Very High Very High
Analgesic 1 95.66 Very High Very High Very High
cocaine 47 94.24 High High
monoamine 12 88.56 High High
Locus ceruleus 92 83.84 Quite High
sSRI 48 82.80 Quite High
Disease Link Frequency Relevance Heat
Stress 39 97.68 Very High Very High Very High
Nociception 3 92.94 High High
Depression 95 86.36 High High
Aplastic Anemia 4 72.40 Quite High
Injury 1 69.84 Quite High
Convulsion 51 66.88 Quite High
Manic Depressive Disorder 8 65.68 Quite High
Drowning 2 35.36 Quite Low
Urological Neuroanatomy 12 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DA involvement in regulation of nociceptive sensitivity and behavioral reactivity in aversive environment; 2. the role of DA and endogenous opioid peptides in endogenous analgesic mechanisms; 3. the functional significance of cerebral DA in organization and realization of various types of an organism's adaptive activity produced by different environmental and homeostatic variables; and 4. the interaction of DA and endogenous opioid peptides in mediation of this activity.
DA Binding (interaction) of associated with nociception, dopamine, analgesic and endogenous opioid
1) Confidence 0.48 Published 1989 Journal Int. J. Neurosci. Section Abstract Doc Link 2562051 Disease Relevance 0.36 Pain Relevance 0.57
-aminobutyric acid; DA, dopamine; DMSO, dimethylsulfoxide; IP, intraperitoneal; IM, immobilization stress; ANOVA, analysis of variance; df, degree of freedom



DA Binding (acid) of associated with stress and dopamine
2) Confidence 0.02 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137594 Disease Relevance 0.31 Pain Relevance 0.24
Despite the doubling of response rates from days 5 to 16, the pattern and magnitudes of DA efflux on the two test days were not statistically different (maximal increase of 69±16% on day 5 and 71±28% on day 16), as a two-way repeated measures ANOVA failed to show a significant interaction of day × time on DA efflux (F7,98=0.598, p=0.528).
DA Binding (interaction) of associated with dopamine
3) Confidence 0.02 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1820758 Disease Relevance 0 Pain Relevance 0.43
Electrophysiological interactions between NE and DA were mainly studied in the hippocampus.
DA Binding (interactions) of in hippocampus associated with dopamine and hippocampus
4) Confidence 0.00 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0 Pain Relevance 0.63
Given the reciprocal interactions between DA, NE, and 5-HT neurons, it is important to consider the effects of pramipexole on all three systems.
DA Binding (interactions) of in 5-HT neurons associated with dopamine
5) Confidence 0.00 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0.12 Pain Relevance 0.37
This review focuses on NE-DA interactions as demonstrated in electrophysiological and neurochemical studies, as well as on the mechanisms of action of agents with either selective or dual actions on DA and NE.
DA Binding (interactions) of associated with dopamine
6) Confidence 0.00 Published 2010 Journal CNS Neuroscience & Therapeutics Section Abstract Doc Link PMC2904493 Disease Relevance 0.24 Pain Relevance 0.52
Altogether, these observations strengthen the importance of the interactions between DA, NE, and 5-HT systems.


DA Binding (interactions) of associated with dopamine
7) Confidence 0.00 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0.07 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox