INT26583
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
However, when all rats were evaluated collectively, regardless of the duration of treatment, the relative increase in CD4:CD8 T cell ratios in the left (treated) lung compared to the right (untreated) lung was significantly greater among rats receiving gastric fluid compared to those receiving normal saline. | |||||||||||||||
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In contrast, this increase in the CD4:CD8 T cell ratio in the left (treated) lung compared to the right (untreated) lung was not observed after normal saline aspiration (Figure 6). | |||||||||||||||
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There is much evidence that CD4+ T cells could only be detected and initially activated in the lymph nodes, spleen and mucosal lymphoid tissues. | |||||||||||||||
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The estimated mean annual increase in CD4 count for individuals aged < and ? | |||||||||||||||
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Concomitant administration of SP with the non-peptide Neurokinin-1 receptor (NK1R) antagonist SR140333 completely inhibited the SP-mediated augmentation of Con A-induced PBL proliferation and IL-2 production as well as of CD4+ CD25+ and CD4+ RT1B+ T cell numbers in normal and capsaicin-treated rats. | |||||||||||||||
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This abnormal activation of CD4+ T lymphocytes correlates with a more intense and more diverse production of alloantibodies in TLT than in canonical secondary lymphoid organs. | |||||||||||||||
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Although providing a plausible explanation for the increased amount of alloantibody produced in adventitial TLT, the mere over-activation of CD4+ T cells cannot explain the more diverse repertoire of intragraft humoral response. | |||||||||||||||
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Moreover, the ratio between the number of CD4+ T cells and mature DC was also increased in TLT (Figure 3A, right panel), making increased priming by DC an unlikely sufficient explanation for the adventitial stochastic over-activation of CD4+ T cells. | |||||||||||||||
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The activation of a CD4+ T lymphocyte requires the presentation of the adequate MHC class II-peptide complex (specifically recognized by the TCR of the T cell) by a mature recipient antigen presenting cells (APC) expressing costimulatory molecules [25]. | |||||||||||||||
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Since the activation of CD4+ T cells is critically depend upon professional antigen presenting cells, the number and the proportion of mature dendritic cells (DC) were compared in adventitial TLT, draining lymph node and spleen. | |||||||||||||||
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In particular, TLT CD4+ T cell activation i) is quantitatively increased, ii) is characterized by the activation of a broader range of T cell clones, iii) is stochastic, i.e. characterized by the absence of shared pattern of TCR perturbation in genetically identical couples of donors and recipients. | |||||||||||||||
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Accordingly, we observed a drastic increase in the percentage of activated CD4+ T cell in intragraft TLT, in both murine experimental model and human samples. | |||||||||||||||
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Accordingly, we observed a drastic increase in the percentage of activated CD4+ T cell in intragraft TLT, in both murine experimental model and human samples. | |||||||||||||||
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Over-activation of CD4+ T lymphocytes in TLT | |||||||||||||||
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Indinavir sulfate is a protease inhibitor that has been found to be extremely effective in increasing CD4+ cell counts and in decreasing HIV-RNA titers in patients with HIV and AIDS. | |||||||||||||||
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Bronchoalveolar lavage specimens from the left (treated) lungs exhibited consistently higher macrophages and T cells with an increased CD4:CD8 T cell ratio after treatment with gastric fluid compared to normal saline. | |||||||||||||||
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Previous studies indicated that autoreactive CD4+ T cells and mononuclear cells have a role in the myocardial inflammatory infiltration and the production of cytokines in EAM rats; however, the role of MTX on the function of circulating T cells and mononuclear cells still requires further investigation. | |||||||||||||||
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Overall, the adjusted risk of having elevated total cholesterol increased by 31% per twofold increase in CD4 cell count [OR, 1.31; IC95%: 1.16-1.47 per log2CD4, P < 0.001] (Fig. 1). | |||||||||||||||
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Finally, the elevated levels of CD5+CD4+ and CD5+CD8+ may be explained by their possible role in the pathogenesis of lung fibrosis, which is also supported by the presence of macrophages in the BALf and lung parenchyma of ischemic animals 3, 7, and 90 days after reperfusion, since they are also thought to be important mediators in the regulation of fibroblast function [37,38,57,58]. | |||||||||||||||
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Combination therapy comprising amprenavir and other antiretroviral agents (abacavir, zidovudine, lamivudine, indinavir, saquinavir or nelfinavir) decreased viral load and increased CD4+ cell counts in patients with HIV infection. | |||||||||||||||
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