INT26583

Context Info Confidence 0.54 First Reported 1989 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 40 Total Number 41 Disease Relevance 21.96 Pain Relevance 4.83

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)

Anatomy Link Frequency T cell 17 lymphocyte 3 plasma 2 lymphoid tissue 2 macrophages 1 Cd4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat substance P 8 99.80 antagonist 2 99.06 Inflammation 236 98.42 qutenza 6 97.92 Inflammatory mediators 15 97.36 fibrosis 118 96.68 cytokine 142 95.60 imagery 8 95.28 methotrexate 110 93.84 headache 10 92.60

Disease Link Frequency Relevance Heat Stroke 37 99.84 Disorder Of Lipid Metabolism 36 99.40 Reperfusion Injury 102 99.20 Acquired Immune Deficiency Syndrome Or Hiv Infection 453 98.96 Infection 112 98.60 INFLAMMATION 297 98.42 Toxicity 13 98.32 Heart Rate Under Development 49 98.00 Immune Reconstitution Inflammatory Syndrome 555 97.44 Pulmonary Fibrosis 25 96.88

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However, when all rats were evaluated collectively, regardless of the duration of treatment, the relative increase in CD4:CD8 T cell ratios in the left (treated) lung compared to the right (untreated) lung was significantly greater among rats receiving gastric fluid compared to those receiving normal saline.

Positive_regulation (increase) of CD4 in T cell

1) Confidence 0.54 Published 2007 Journal Respir Res Section Body Doc Link PMC2213655 Disease Relevance 0 Pain Relevance 0.08

In contrast, this increase in the CD4:CD8 T cell ratio in the left (treated) lung compared to the right (untreated) lung was not observed after normal saline aspiration (Figure 6).

Positive_regulation (increase) of CD4 in T cell

2) Confidence 0.54 Published 2007 Journal Respir Res Section Body Doc Link PMC2213655 Disease Relevance 0 Pain Relevance 0

There is much evidence that CD4+ T cells could only be detected and initially activated in the lymph nodes, spleen and mucosal lymphoid tissues.

Positive_regulation (activated) of CD4 in lymphoid tissues

3) Confidence 0.48 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.09 Pain Relevance 0

The estimated mean annual increase in CD4 count for individuals aged < and ?

Positive_regulation (increase) of CD4

4) Confidence 0.47 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC3022663 Disease Relevance 0.55 Pain Relevance 0

Concomitant administration of SP with the non-peptide Neurokinin-1 receptor (NK1R) antagonist SR140333 completely inhibited the SP-mediated augmentation of Con A-induced PBL proliferation and IL-2 production as well as of CD4+ CD25+ and CD4+ RT1B+ T cell numbers in normal and capsaicin-treated rats.

Positive_regulation (augmentation) of CD4 in T cell associated with qutenza, antagonist and substance p

5) Confidence 0.46 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10378865 Disease Relevance 0 Pain Relevance 0.86

This abnormal activation of CD4+ T lymphocytes correlates with a more intense and more diverse production of alloantibodies in TLT than in canonical secondary lymphoid organs.

Positive_regulation (activation) of CD4 in T lymphocytes

6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0.07 Pain Relevance 0.03

Although providing a plausible explanation for the increased amount of alloantibody produced in adventitial TLT, the mere over-activation of CD4+ T cells cannot explain the more diverse repertoire of intragraft humoral response.

Positive_regulation (activation) of CD4 in mere

7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0 Pain Relevance 0

Moreover, the ratio between the number of CD4+ T cells and mature DC was also increased in TLT (Figure 3A, right panel), making increased priming by DC an unlikely sufficient explanation for the adventitial stochastic over-activation of CD4+ T cells.

Positive_regulation (activation) of CD4 in T cells

8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0 Pain Relevance 0

The activation of a CD4+ T lymphocyte requires the presentation of the adequate MHC class II-peptide complex (specifically recognized by the TCR of the T cell) by a mature recipient antigen presenting cells (APC) expressing costimulatory molecules [25].

Positive_regulation (activation) of CD4 in T lymphocyte

9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0 Pain Relevance 0

Since the activation of CD4+ T cells is critically depend upon professional antigen presenting cells, the number and the proportion of mature dendritic cells (DC) were compared in adventitial TLT, draining lymph node and spleen.

Positive_regulation (activation) of CD4 in professional antigen presenting cells

10) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0 Pain Relevance 0

In particular, TLT CD4+ T cell activation i) is quantitatively increased, ii) is characterized by the activation of a broader range of T cell clones, iii) is stochastic, i.e. characterized by the absence of shared pattern of TCR perturbation in genetically identical couples of donors and recipients.

Positive_regulation (activation) of CD4 in T cell

11) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0.08 Pain Relevance 0.04

Accordingly, we observed a drastic increase in the percentage of activated CD4+ T cell in intragraft TLT, in both murine experimental model and human samples.

Positive_regulation (increase) of CD4 in T cell

12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0 Pain Relevance 0

Accordingly, we observed a drastic increase in the percentage of activated CD4+ T cell in intragraft TLT, in both murine experimental model and human samples.

Positive_regulation (activated) of CD4 in T cell

13) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0 Pain Relevance 0

Over-activation of CD4+ T lymphocytes in TLT

Positive_regulation (activation) of CD4 in T lymphocytes

14) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0 Pain Relevance 0

Indinavir sulfate is a protease inhibitor that has been found to be extremely effective in increasing CD4+ cell counts and in decreasing HIV-RNA titers in patients with HIV and AIDS.

Positive_regulation (increasing) of CD4 associated with acquired immune deficiency syndrome or hiv infection

15) Confidence 0.37 Published 2000 Journal Curr Opin Urol Section Abstract Doc Link 11148725 Disease Relevance 0.76 Pain Relevance 0.05

Bronchoalveolar lavage specimens from the left (treated) lungs exhibited consistently higher macrophages and T cells with an increased CD4:CD8 T cell ratio after treatment with gastric fluid compared to normal saline.

Positive_regulation (increased) of CD4 in macrophages

16) Confidence 0.36 Published 2007 Journal Respir Res Section Abstract Doc Link PMC2213655 Disease Relevance 0.60 Pain Relevance 0.22

Previous studies indicated that autoreactive CD4+ T cells and mononuclear cells have a role in the myocardial inflammatory infiltration and the production of cytokines in EAM rats; however, the role of MTX on the function of circulating T cells and mononuclear cells still requires further investigation.

Positive_regulation (autoreactive) of CD4 in T cells associated with inflammation, methotrexate, acute myocarditis and cytokine

17) Confidence 0.32 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768010 Disease Relevance 1.45 Pain Relevance 0.84

Overall, the adjusted risk of having elevated total cholesterol increased by 31% per twofold increase in CD4 cell count [OR, 1.31; IC95%: 1.16-1.47 per log2CD4, P < 0.001] (Fig. 1).

Positive_regulation (increase) of CD4 associated with disorder of lipid metabolism

18) Confidence 0.26 Published 2008 Journal The Open AIDS Journal Section Body Doc Link PMC2556198 Disease Relevance 1.14 Pain Relevance 0

Finally, the elevated levels of CD5+CD4+ and CD5+CD8+ may be explained by their possible role in the pathogenesis of lung fibrosis, which is also supported by the presence of macrophages in the BALf and lung parenchyma of ischemic animals 3, 7, and 90 days after reperfusion, since they are also thought to be important mediators in the regulation of fibroblast function [37,38,57,58].

Positive_regulation (elevated) of CD4 in lung associated with fibrosis and pulmonary fibrosis

19) Confidence 0.26 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.50 Pain Relevance 0.09

Combination therapy comprising amprenavir and other antiretroviral agents (abacavir, zidovudine, lamivudine, indinavir, saquinavir or nelfinavir) decreased viral load and increased CD4+ cell counts in patients with HIV infection.

Positive_regulation (increased) of CD4 associated with acquired immune deficiency syndrome or hiv infection and infection

20) Confidence 0.21 Published 1998 Journal Drugs Section Abstract Doc Link 9617598 Disease Relevance 0.87 Pain Relevance 0.09

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