INT265833

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANGPT2) signal transduction (ANGPT2) extracellular space (ANGPT2)
extracellular region (ANGPT2) plasma membrane (ANGPT2) nucleus (ANGPT2)
Anatomy Link Frequency
smooth muscle cells 2
ANGPT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 14 99.04 Very High Very High Very High
Inflammation 2 90.32 High High
Pain 7 5.00 Very Low Very Low Very Low
beta blocker 7 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 90.32 High High
Stress 8 88.72 High High
Increased Venous Pressure Under Development 6 88.64 High High
Atherosclerosis 34 81.16 Quite High
Pathologic Constriction 3 63.16 Quite High
Peripheral Arterial Disease 61 61.56 Quite High
Coronary Heart Disease 2 56.48 Quite High
Ventricular Remodeling 2 52.12 Quite High
Myocardial Infarction 9 48.48 Quite Low
Cardiomyopathy 1 46.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACE-I alter this balance by decreasing the formation of Ang II and the degradation of bradykinin (Figure 1): the bradykinin is potentiated and NO is released to a greater extent, resulting in decreased migration and proliferation of vascular smooth muscle cells, decreased accumulation and activation of inflammatory cells, decreased oxidative stress, and improved endothelial function.


Negative_regulation (decreasing) of Ang II Binding (formation) of in smooth muscle cells associated with stress, inflammation and bradykinin
1) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.82 Pain Relevance 0.24

General Comments

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