INT26584

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Context Info
Confidence 0.75
First Reported 1989
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 76
Total Number 77
Disease Relevance 24.03
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nes) intracellular (Nes) cytoplasm (Nes)
Anatomy Link Frequency
neural 7
stem cell 6
neuronal 5
astrocytes 4
brain 3
Nes (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 181 99.56 Very High Very High Very High
Kappa opioid receptor 160 98.56 Very High Very High Very High
Central nervous system 317 98.36 Very High Very High Very High
cerebral cortex 26 97.80 Very High Very High Very High
Nerve growth factor 32 95.80 Very High Very High Very High
Potency 17 92.32 High High
cytokine 220 91.00 High High
Hippocampus 383 89.28 High High
GABAergic 30 88.00 High High
neurotrophin 3 108 87.72 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 103 99.88 Very High Very High Very High
Infection 695 99.68 Very High Very High Very High
Cancer 219 99.44 Very High Very High Very High
Viral Infection 166 99.40 Very High Very High Very High
Cytomegalovirus Infection 675 99.32 Very High Very High Very High
Neurodegenerative Disease 679 99.30 Very High Very High Very High
Convulsion 319 97.84 Very High Very High Very High
Apoptosis 65 97.24 Very High Very High Very High
Skin Cancer 3 96.88 Very High Very High Very High
Anaerobic Bacterial Infections 2 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In their study, some reactive astrocytes expressed nestin during early cancer cell invasion.
Gene_expression (expressed) of nestin in astrocytes associated with cancer
1) Confidence 0.75 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 1.19 Pain Relevance 0.04
Figure 2B shows the coexpression of nestin and NOS-1 in the differentiation medium of the hESC culture.
Gene_expression (coexpression) of nestin
2) Confidence 0.75 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0.07 Pain Relevance 0.03
NOS-1–expressing cells accumulated in the center, while nestin-expressing cells diffused throughout the entire area.
Gene_expression (expressing) of nestin
3) Confidence 0.75 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0 Pain Relevance 0
These tNSCs showed neurosphere formation and expressed high levels of early neuroectodermal markers, such as the proneural genes NeuroD1, Neurog2, and Olig2, the NSC markers Nestin and Musashi1, and the proliferation markers Ki67 and BrdU (5-bromo-2-deoxyuridine).
Gene_expression (expressed) of Nestin
4) Confidence 0.61 Published 2006 Journal Stem Cells Section Abstract Doc Link 16373695 Disease Relevance 0.23 Pain Relevance 0.33
Nestin (Nes) is a component of intermediate filaments and is expressed in neural progenitor cells [26].
Gene_expression (expressed) of Nestin in neural
5) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.28 Pain Relevance 0.07
In the eye, SP cells in the cornea localize to the limbal epithelium and have been shown to possess stem cell-like properties, including markedly higher expression levels of Bmi-1, Nes, Notch1, and p63 compared to non-SP cells [7,9].
Gene_expression (levels) of Nes in stem cell
6) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.23 Pain Relevance 0.03
Nestin (Nes) is a component of intermediate filaments and is expressed in neural progenitor cells [26].
Gene_expression (expressed) of Nes in neural
7) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.28 Pain Relevance 0.07
In the eye, SP cells in the cornea localize to the limbal epithelium and have been shown to possess stem cell-like properties, including markedly higher expression levels of Bmi-1, Nes, Notch1, and p63 compared to non-SP cells [7,9].
Gene_expression (expression) of Nes in stem cell
8) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.23 Pain Relevance 0.03
Results: We have shown the confocal image of stage 1 human embryonic stem cells coexpressing nestin and nitric oxide synthase-1.
Gene_expression (coexpressing) of nestin in stage 1
9) Confidence 0.58 Published 2010 Journal Eplasty Section Abstract Doc Link PMC2885864 Disease Relevance 0 Pain Relevance 0.03
In the present study, double labeling revealed that BrdU positive nuclei were expressed by microglia or nestin-expressing stem cells but not in astrocytes in the CNS compartment of TREZ.
Gene_expression (expressing) of nestin in astrocytes associated with central nervous system
10) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.30 Pain Relevance 0.39
Migratory, neuroblast-like type-3 cells are DCX-positive but do not express Nestin-GFP anymore.
Neg (not) Gene_expression (express) of Nestin-GFP in neuroblast
11) Confidence 0.51 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.34 Pain Relevance 0.04
Expression of the NSC marker nestin in our ESNP grafts was not significantly altered by prior seizures (Figure 7A).
Gene_expression (Expression) of nestin associated with convulsion
12) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 1.01 Pain Relevance 0.04
In addition to neural cell types, nestin is expressed in the hair follicular bulge as well [46].
Gene_expression (expressed) of nestin in hair
13) Confidence 0.48 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.60 Pain Relevance 0.07
g/ml) generated as previously described (McLaughlin et al., 2004), rat anti-CD11b (1:200, Serotec, Oxford, UK), rabbit anti-GFAP (1:1000, Dako, Denmark), mouse anti-nestin (Abcam, Cambridge, MA) and mouse anti-BrdU (6 ?
Gene_expression (described) of nestin
14) Confidence 0.47 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.23 Pain Relevance 0.24
However, it appeared that comparatively less staining was observed in the population of Nestin-positive type 1 cells (Fig. 4B) and type 2a cells.
Gene_expression (population) of Nestin
15) Confidence 0.44 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.19 Pain Relevance 0.03
CB1 and Nestin content in 1 ?
Gene_expression (content) of Nestin
16) Confidence 0.44 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0 Pain Relevance 0
Our findings indicate that NSCs expressing CD133 and nestin are the prime target cells along with CD24(hi) neuroblasts.
Gene_expression (expressing) of nestin in neuroblasts
17) Confidence 0.44 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.63 Pain Relevance 0.03
MCMV brain infection reduces CD133(+) cell number and alters nestin expression
Gene_expression (expression) of nestin in brain associated with cytomegalovirus infection and infection
18) Confidence 0.44 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 1.05 Pain Relevance 0
Antibodies were diluted as follows: mouse anti-nestin, 1?
Gene_expression (diluted) of nestin
19) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0
Some of the administered cells were found in the parenchyma of the gray matter and expressed Nestin.
Gene_expression (expressed) of Nestin in gray matter
20) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.52 Pain Relevance 0.24

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