INT265879

Context Info Confidence 0.11 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.37 Pain Relevance 0.03

cytosol (FOXO1) nucleoplasm (FOXO1) signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1) nucleus (FOXO1)

Anatomy Link Frequency neurons 1 IGF1 (Homo sapiens) FOXO1 (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 1 50.28 Inflammatory marker 4 50.00 Central nervous system 1 46.84 projection neuron 1 7.28 Inflammation 4 5.00 cytokine 2 5.00 imagery 2 5.00 carpal tunnel syndrome 1 5.00 rheumatoid arthritis 1 5.00 Serotonin 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 8 100.00 Death 6 93.16 Obesity 7 87.76 Aging 4 66.48 Atherosclerosis 12 65.92 Cerebrovascular Disease 3 64.32 Cognitive Disorder 2 62.32 Dementia 2 60.48 Cardiovascular Disease 12 51.92 Cv General 4 Under Development 1 50.28

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

High glucose also induces loss of the initiator caspase-9 and increases caspase-3 cleavage, effects blocked by IGF-I, suggesting that IGF-I prevents apoptosis in DRG neurons by regulating PI3K/Akt pathway effectors, including GSK-3beta, CREB, and FKHR, and by blocking caspase activation (Leinninger et al 2004).

IGF-I Regulation (regulating) of FKHR in neurons associated with apoptosis

1) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 1.37 Pain Relevance 0.03

General Comments

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