INT265886

Context Info Confidence 0.11 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 3.06 Pain Relevance 0.23

signal transduction (IGF1, AKT1) cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1) small molecule metabolic process (AKT1) enzyme binding (AKT1)

Anatomy Link Frequency neuronal 1 DRG 1 IGF1 (Homo sapiens) AKT1 (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 3 84.88 Central nervous system 3 81.44 Inflammatory marker 12 50.00 Inflammation 12 5.00 cytokine 6 5.00 imagery 6 5.00 carpal tunnel syndrome 3 5.00 rheumatoid arthritis 3 5.00 Serotonin 3 5.00 antagonist 3 5.00

Disease Link Frequency Relevance Heat Apoptosis 24 97.60 Death 18 94.52 Cv General 4 Under Development 3 84.88 Stress 21 84.00 Injury 6 83.00 Obesity 21 51.04 INFLAMMATION 24 50.00 Aging 12 29.76 Atherosclerosis 36 29.20 Cerebrovascular Disease 9 27.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IGF-I regulates survival at the nuclear level through accumulation of phospho-Akt in DRG neuronal nuclei, increased CREB-mediated transcription, and nuclear exclusion of FKHR.

IGF-I Positive_regulation (accumulation) of Akt in neuronal

1) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 1.10 Pain Relevance 0.07

Dorsal root ganglia (DRG) neurons express IGF-I receptors (IGF-IR), and IGF-I activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.

IGF-I Positive_regulation (activates) of Akt in DRG

2) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.99 Pain Relevance 0.08

IGF-I stimulation of the PI3K/Akt pathway phosphorylates three known Akt effectors: the survival transcription factor cyclic AMP response element binding protein (CREB) and the pro-apoptotic effector proteins glycogen synthase kinase-3beta (GSK-3beta) and forkhead (FKHR).

IGF-I Positive_regulation (stimulation) of Akt associated with apoptosis

3) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.97 Pain Relevance 0.08

General Comments

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