INT265892

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.96
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) signal transduction (IGF1) extracellular space (IGF1)
extracellular region (IGF1) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
Anatomy Link Frequency
DRG 1
IGF1 (Homo sapiens)
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 2 84.88 Quite High
Central nervous system 2 81.44 Quite High
Inflammatory marker 8 50.00 Quite Low
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 16 97.60 Very High Very High Very High
Death 12 94.52 High High
Cv General 4 Under Development 2 84.88 Quite High
Stress 14 84.00 Quite High
Injury 4 83.00 Quite High
INFLAMMATION 16 50.00 Quite Low
Obesity 14 29.08 Quite Low
Growth Hormone Deficiency 24 20.96 Low Low
Diabetes Mellitus 14 17.88 Low Low
Coronary Artery Disease 8 17.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dorsal root ganglia (DRG) neurons express IGF-I receptors (IGF-IR), and IGF-I activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.
IGF-I Positive_regulation (activates) of PI3K in DRG
1) Confidence 0.18 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.99 Pain Relevance 0.08
IGF-I stimulation of the PI3K/Akt pathway phosphorylates three known Akt effectors: the survival transcription factor cyclic AMP response element binding protein (CREB) and the pro-apoptotic effector proteins glycogen synthase kinase-3beta (GSK-3beta) and forkhead (FKHR).
IGF-I Positive_regulation (stimulation) of PI3K associated with apoptosis
2) Confidence 0.16 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.97 Pain Relevance 0.08

General Comments

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