INT265915

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.65
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
coronary artery 2
platelet 2
Adp (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 42 90.00 High High
Calcium channel 1 81.68 Quite High
beta blocker 1 75.04 Quite High
cINOD 1 34.72 Quite Low
cva 36 33.32 Quite Low
imagery 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 72 96.28 Very High Very High Very High
Cv General 4 Under Development 16 89.60 High High
Nicotine Addiction 5 77.32 Quite High
Chronic Renal Failure 2 72.68 Quite High
Diabetes Mellitus 5 71.64 Quite High
Critical Illness 17 50.00 Quite Low
Hemorrhage 2 49.68 Quite Low
Stroke 12 41.12 Quite Low
INFLAMMATION 2 34.48 Quite Low
Pressure And Volume Under Development 12 21.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subacute thrombosis of coronary stents in the CREST study was found to be more common in patients with hyporesponsiveness to clopidogrel.42 Clopidogrel is a pro-drug and its active metabolite irreversibly inhibits the binding of P2Y12 ADP receptor on platelets.43 Such metabolism invokes the possibility of the concurrent use of other medications as contributing factors to hyporesponsiveness in patients with coronary artery stenting.
Negative_regulation (inhibits) of ADP receptor Binding (binding) of in coronary artery associated with thrombosis
1) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788601 Disease Relevance 0.32 Pain Relevance 0.33
Clopidogrel (Plavix), a thienopyridine derivative, selectively inhibits the binding of ADP to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein IIb/IIIa complex, thereby inhibiting platelet aggregation and reducing the formation of arterial and venous thrombi (Coukell and Markham 1997).
Negative_regulation (inhibits) of ADP Binding (binding) of in platelet
2) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663458 Disease Relevance 0.33 Pain Relevance 0.11

General Comments

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