INT265915

Context Info Confidence 0.01 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.65 Pain Relevance 0.44

Anatomy Link Frequency coronary artery 2 platelet 2 Adp (Mus musculus)

Pain Link Frequency Relevance Heat aspirin 42 90.00 Calcium channel 1 81.68 beta blocker 1 75.04 cINOD 1 34.72 cva 36 33.32 imagery 9 5.00 agonist 6 5.00 Angina 3 5.00 Central nervous system 2 5.00 ischemia 2 5.00

Disease Link Frequency Relevance Heat Thrombosis 72 96.28 Cv General 4 Under Development 16 89.60 Nicotine Addiction 5 77.32 Chronic Renal Failure 2 72.68 Diabetes Mellitus 5 71.64 Critical Illness 17 50.00 Hemorrhage 2 49.68 Stroke 12 41.12 INFLAMMATION 2 34.48 Pressure And Volume Under Development 12 21.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Subacute thrombosis of coronary stents in the CREST study was found to be more common in patients with hyporesponsiveness to clopidogrel.42 Clopidogrel is a pro-drug and its active metabolite irreversibly inhibits the binding of P2Y12 ADP receptor on platelets.43 Such metabolism invokes the possibility of the concurrent use of other medications as contributing factors to hyporesponsiveness in patients with coronary artery stenting.

Negative_regulation (inhibits) of ADP receptor Binding (binding) of in coronary artery associated with thrombosis

1) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788601 Disease Relevance 0.32 Pain Relevance 0.33

Clopidogrel (Plavix), a thienopyridine derivative, selectively inhibits the binding of ADP to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein IIb/IIIa complex, thereby inhibiting platelet aggregation and reducing the formation of arterial and venous thrombi (Coukell and Markham 1997).

Negative_regulation (inhibits) of ADP Binding (binding) of in platelet

2) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663458 Disease Relevance 0.33 Pain Relevance 0.11

General Comments

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