INT265959

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Context Info
Confidence 0.54
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.33
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prnd)
Anatomy Link Frequency
brain 1
central nervous system 1
Prnd (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 12 98.74 Very High Very High Very High
Action potential 3 34.40 Quite Low
iatrogenic 18 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
Demyelination 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 41 99.92 Very High Very High Very High
Drug Induced Neurotoxicity 12 99.40 Very High Very High Very High
Ataxia 6 95.68 Very High Very High Very High
Targeted Disruption 165 88.80 High High
Lifespan 3 79.36 Quite High
Peritonitis 3 79.08 Quite High
Stab Wounds 3 75.24 Quite High
Abdominal Injuries 3 72.84 Quite High
Infection 34 67.92 Quite High
Creutzfeldt Jakob Disease 267 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Algorithms for using DPL, FAST, and CT scanning in both penetrating and blunt abdominal trauma are shown in Figures 5 and 6.


Gene_expression (using) of DPL associated with injury
1) Confidence 0.54 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2663535 Disease Relevance 0.97 Pain Relevance 0
The severity of neurotoxicity correlates with the level of Dpl expression [134] and can be rescued by PrPC expression [135], indicating that PrPC, Dpl and ?
Gene_expression (expression) of Dpl associated with drug induced neurotoxicity
2) Confidence 0.32 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.43 Pain Relevance 0.06
Intriguingly, the Doppel protein (Dpl) [132], which has a similar structure to N-terminally truncated PrP, causes a similar cerebellar effect when ectopically expressed in the brain [133].
Gene_expression (expressed) of Dpl in brain
3) Confidence 0.28 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.47 Pain Relevance 0
Recently the protein Sho has been demonstrated to be a glycosylphosphatidylinositol (GPI)-anchored neuronal glycoprotein present in the central nervous system (CNS) from early postnatal life that can counteract the neurotoxic effects of either Dpl or ?
Gene_expression (effects) of Dpl in central nervous system associated with central nervous system
4) Confidence 0.24 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.46 Pain Relevance 0.10

General Comments

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