INT2660

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Context Info
Confidence 0.49
First Reported 1979
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 58
Total Number 62
Disease Relevance 33.74
Pain Relevance 18.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fabp6) cytoplasm (Fabp6)
Anatomy Link Frequency
blood 9
plasma 3
parasympathetic 3
sympathetic 3
heart 3
Fabp6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 197 100.00 Very High Very High Very High
Clonidine 65 100.00 Very High Very High Very High
Neuropeptide 16 100.00 Very High Very High Very High
medulla 15 100.00 Very High Very High Very High
backache 14 100.00 Very High Very High Very High
Calcitonin gene-related peptide 14 100.00 Very High Very High Very High
Hippocampus 14 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
tolerance 2 99.78 Very High Very High Very High
Spinal cord 10 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 331 100.00 Very High Very High Very High
Diabetes Mellitus 250 100.00 Very High Very High Very High
Heart Rate Under Development 213 100.00 Very High Very High Very High
Sprains And Strains 65 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 24 100.00 Very High Very High Very High
Pressure And Volume Under Development 16 100.00 Very High Very High Very High
Low Back Pain 14 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Bradycardia 1 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 52 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This decrease in arteriolar tone in the adrenalectomized SHR could in turn be restored to the hypertensive levels with dexamethasone but not aldosterone.
Negative_regulation (decrease) of SHR associated with hypertension and dexamethasone
1) Confidence 0.49 Published 1995 Journal Int J Microcirc Clin Exp Section Abstract Doc Link 8721440 Disease Relevance 0.40 Pain Relevance 0.24
The fact that the clonidine induced decrease in adrenal catecholamine secretion rates was approximately parallel to the decrease in preganglionic adrenal nerve discharges in the nerve intact SHR, suggests that the central action of clonidine is important in the adrenal suppressant effect relative to its peripheral action.
Negative_regulation (decrease) of SHR in nerve associated with catecholamine and clonidine
2) Confidence 0.49 Published 1983 Journal Hokkaido Igaku Zasshi Section Abstract Doc Link 6873866 Disease Relevance 0.07 Pain Relevance 0.87
At 6-8 wk capillary density was reduced in the SHR.
Negative_regulation (reduced) of SHR in capillary
3) Confidence 0.49 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7114235 Disease Relevance 0.51 Pain Relevance 0.09
Although resting cardiac index of the SHR was comparable to that of WKY and NWR at all ages, the peak cardiac output and peak stroke volume per gram of left ventricle determined during a rapid intravenous infusion of Tyrode solution was markedly reduced in the SHR only at 90 wk of age.
Negative_regulation (reduced) of SHR in ventricle associated with stroke
4) Confidence 0.49 Published 1979 Journal Am. J. Physiol. Section Abstract Doc Link 495731 Disease Relevance 0.73 Pain Relevance 0.09
Thus, the present study demonstrates that there is a specific loss of alpha 2-adrenoceptors in the medulla oblongata of SHR and SHRSP that may be partly involved in the pathogenesis of spontaneous hypertension.
Negative_regulation (loss) of SHR in medulla oblongata associated with medulla and hypertension
5) Confidence 0.42 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2471890 Disease Relevance 0.37 Pain Relevance 0.39
The loss of accommodation in the neurons of SHR was not due to a loss of M-current, a potassium current involved in controlling spike frequency adaptation in sympathetic neurons.
Negative_regulation (loss) of SHR in neurons
6) Confidence 0.42 Published 1985 Journal Hypertension Section Abstract Doc Link 3980070 Disease Relevance 0.16 Pain Relevance 0.19
Ca2+ supplementation prevented the exaggerated depressor response to clonidine in high NaCl-fed SHR-S, but did not reduce the response in SHR-S on the basal NaCl diet.
Negative_regulation (prevented) of SHR associated with clonidine
7) Confidence 0.41 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2468929 Disease Relevance 0.20 Pain Relevance 0.44
When superfusion solution PO2 was elevated by changing the gas equilibration mixture from 0 to 5% O2, neurally blocked 3A and 4A of SHR exhibited a significantly greater constriction and a higher incidence of complete closure than those of their age-matched WKY controls.
Negative_regulation (blocked) of SHR
8) Confidence 0.40 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3706551 Disease Relevance 0.32 Pain Relevance 0.10
However, none of these factors were thought to strongly discriminate between ILBP and MLBP.
Negative_regulation (discriminate) of ILBP associated with backache
9) Confidence 0.37 Published 2009 Journal Man Ther Section Abstract Doc Link 18555728 Disease Relevance 1.97 Pain Relevance 1.79
Continuous recordings of ABP and HR made in conscious, unrestrained, young 1-, 2-, 3-, and 6-mo-old rats show that power spectra of HR fluctuations were similar in both strains, whereas ABP fluctuations were significantly different in the low, presumably vasomotor frequency range being reduced in SHR as compared with age-matched WKY rats.
Negative_regulation (reduced) of SHR associated with sprains and strains
10) Confidence 0.36 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3605364 Disease Relevance 0.43 Pain Relevance 0.13
Infusion of DZ increased cardiac output and stroke volume and decreased heart rate, left ventricular and arterial pressures, and systemic vascular resistance in SHR.
Negative_regulation (decreased) of SHR in heart associated with stroke and bradycardia
11) Confidence 0.36 Published 1986 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2422460 Disease Relevance 0.43 Pain Relevance 0.08
Adrenalectomy led to a reduction in the elevated blood pressure in SHR to normotensive levels, which could be restored to its hypertensive level by treatment with dexamethasone.
Negative_regulation (reduction) of SHR in blood associated with pressure and volume under development, hypertension and dexamethasone
12) Confidence 0.36 Published 1995 Journal Int J Microcirc Clin Exp Section Abstract Doc Link 8721440 Disease Relevance 0.41 Pain Relevance 0.24
At 12-14 and 16-18 wk there was an elevated level of arteriolar vasoconstriction in the SHR that was masked in any one state by the closure of the smaller arterioles.
Negative_regulation (masked) of SHR in arterioles associated with increased venous pressure under development
13) Confidence 0.36 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7114235 Disease Relevance 0.49 Pain Relevance 0.07
In the SHR, a decrease in blood pressure occurred.
Negative_regulation (decrease) of SHR in blood associated with pressure volume 2 under development
14) Confidence 0.36 Published 1981 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6762984 Disease Relevance 0.38 Pain Relevance 0.24
The aim of the present study was to answer the question whether the degree of tolerance to oxygen deprivation in hearts of spontaneously hypertensive rats (SHR) may be sex-dependent.
Negative_regulation (deprivation) of SHR in hearts associated with hypertension and tolerance
15) Confidence 0.36 Published 2007 Journal Physiol Res Section Abstract Doc Link 16792462 Disease Relevance 0.50 Pain Relevance 0.26
However, in NT and SHR made morphine-dependent (3 X 75 mg morphine pellets s.c.) and in hypophysectomised rats the increase in blood pressure was significantly reduced compared to the untreated or sham operated control groups, with a decrease in both the slope of the dose-response curve and a decrease in the average response.
Negative_regulation (reduced) of SHR in blood associated with pressure and volume under development and morphine
16) Confidence 0.36 Published 1986 Journal Clin Exp Hypertens A Section Abstract Doc Link 3731506 Disease Relevance 0.38 Pain Relevance 0.66
These studies indicate that the function of the cardiac sympathetic varicosity matures early (by 4 weeks) and overall there is very little impairment in SHR versus WKY rat atria.
Negative_regulation (impairment) of SHR in sympathetic
17) Confidence 0.35 Published 1989 Journal J. Hypertens. Section Abstract Doc Link 2549123 Disease Relevance 0.05 Pain Relevance 0.16
Brainstem noradrenergic inhibition of acute nociception in the hotplate test is enhanced in the SHR rat, but brainstem noradrenergic contribution to persistent nociceptive processing in the formalin test is reduced in the SHR rat.
Negative_regulation (reduced) of SHR in Brainstem associated with nociception and medulla
18) Confidence 0.35 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10984626 Disease Relevance 1.25 Pain Relevance 0.62
Denervation of the right vagal nerve trunk with associated cardiopulmonary baroreceptor afferents resulted in a reduction of the SHR hypoalgesic behavior and produced a hyperalgesic behavior in WKY as compared to age-matched sham operated controls over a 4 week period.
Negative_regulation (reduction) of SHR in nerve trunk associated with hyperalgesia and sprains and strains
19) Confidence 0.35 Published 1982 Journal Brain Res. Section Abstract Doc Link 6122488 Disease Relevance 1.16 Pain Relevance 0.37
Subcutaneous administration of the peripherally acting ganglionic blocker hexamethonium bromide at a dose which lowered mean arterial blood pressure and thus decreased tonic baroreceptor stimulation, concomitantly reversed the SHR hypoalgesic behavior and induced a hyperalgesia in WKY.
Negative_regulation (reversed) of SHR in blood associated with hyperalgesia and sprains and strains
20) Confidence 0.35 Published 1982 Journal Brain Res. Section Abstract Doc Link 6122488 Disease Relevance 1.14 Pain Relevance 0.33

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