INT266011

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.61
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mdm2) intracellular (Mdm2) enzyme binding (Mdm2)
protein complex assembly (Mdm2) protein complex (Mdm2) ligase activity (Mdm2)
Mdm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 10 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Viral Infection 2 100.00 Very High Very High Very High
Cancer 198 99.76 Very High Very High Very High
Liposarcoma 48 96.58 Very High Very High Very High
Sarcoma 34 88.92 High High
Myxoid Liposarcoma 2 87.60 High High
Apoptosis 52 79.20 Quite High
Aging 14 78.76 Quite High
Glioma 90 74.80 Quite High
Stress 16 73.92 Quite High
Syndrome 4 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes in the MDM2 gene are known to be a common mechanism in the genesis of liposarcomas.31 The amplification of this gene and its mRNA overexpression can lead to overproduction of MDM2 protein.32 The immunohistochemical analysis reveals nuclear location and overexpression of MDM2 in these tumors with amplification of the MDM2 gene.33
Positive_regulation (overexpression) of Gene_expression (overexpression) of MDM2 associated with liposarcoma and cancer
1) Confidence 0.47 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 1.07 Pain Relevance 0
Although immunohistochemistry can be used to demonstrate MDM2 overexpression, direct correlation between the gene amplification and protein overexpression is not the rule.35 Nevertheless, mutations cause an irregular increase in stable proteins that can be detected by immunohistochemistry.36
Positive_regulation (overexpression) of Gene_expression (overexpression) of MDM2
2) Confidence 0.47 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 0.77 Pain Relevance 0
While approximately half of all human tumors contain a mutation or deletion of TP53, the rest of the tumors often have inactivation of p53 through other mechanisms including viral infection, loss of ARF, or overexpression of MDM2 [21].
Positive_regulation (overexpression) of Gene_expression (overexpression) of MDM2 associated with cancer and viral infection
3) Confidence 0.19 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.34 Pain Relevance 0
While approximately half of all human tumors contain a mutation or deletion of TP53, the rest of the tumors often have inactivation of p53 through other mechanisms including viral infection, loss of ARF, or overexpression of MDM2 [21].
Positive_regulation (inactivation) of Gene_expression (overexpression) of MDM2 associated with cancer and viral infection
4) Confidence 0.19 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.43 Pain Relevance 0

General Comments

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