INT266107

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (MET, SH2B2) plasma membrane (MET, SH2B2) cytosol (SH2B2)
cell proliferation (MET) cytoplasm (SH2B2) signal transducer activity (SH2B2)
MET (Homo sapiens)
SH2B2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 109 99.28 Very High Very High Very High
Pain 19 5.00 Very Low Very Low Very Low
Catecholamine 7 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Fibrositis 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hantavirus Infection 78 97.44 Very High Very High Very High
Pain 19 5.00 Very Low Very Low Very Low
Cognitive Disorder 7 5.00 Very Low Very Low Very Low
Schizophrenia 5 5.00 Very Low Very Low Very Low
Temporomandibular Joint Disorders 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Hyperhomocysteinemia 2 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Cardiovascular Disease 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results suggest that the synonymous and nonsynonymous minor SNPs tested herein do not significantly alter functional effects on COMT enzymatic activity produced by the met158 allele associated with the APS haplotype and the mRNA secondary structure associated with the HPS haplotype and, thus, can be considered neutral.


met158 Binding (associated) of APS associated with catechol-o-methyltransferase and hantavirus infection
1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.67 Pain Relevance 0.15

General Comments

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