INT266162

Context Info Confidence 0.68 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.76 Pain Relevance 0

mitochondrion (POLG) cell death (POLG) aging (POLG) DNA binding (POLG) nucleotidyltransferase activity (POLG) DNA metabolic process (POLG)

Anatomy Link Frequency egg 1 POLG (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 6 40.64 depression 2 5.00 headache 2 5.00 peripheral neuropathy 1 5.00 Neuropathic pain 1 5.00 Osteoarthritis 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Helminth Infection 69 100.00 Lifespan 18 99.92 Parkinson's Disease 7 91.36 Systemic Lupus Erythematosus 1 50.64 Starvation 1 31.56 Dementia 12 21.52 Hearing Impairment 11 19.60 Chronic Progressive External Ophthalmoplegia 5 18.00 Ocular Toxicity (including Many Sub-types) 10 14.72 Sprains And Strains 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Detection of the POLG1 c.2243G>C (p.W748S) mutation

Transcription (Detection) of POLG1

1) Confidence 0.68 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2873323 Disease Relevance 0.05 Pain Relevance 0

Decreased egg laying prolongs lifespan in polg-1 deficient worms

Transcription (worms) of polg-1 in egg associated with helminth infection and lifespan

2) Confidence 0.58 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.71 Pain Relevance 0

General Comments

This test has worked.