INT266251

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.26
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Lhb) molecular_function (Lhb) cellular_component (Lhb)
biological_process (Lhb)
Anatomy Link Frequency
tears 2
neurons 2
Lhb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 136 100.00 Very High Very High Very High
Serotonin 14 99.64 Very High Very High Very High
Raphe 30 99.24 Very High Very High Very High
Pain 9 98.48 Very High Very High Very High
depression 10 98.04 Very High Very High Very High
IPN 86 93.16 High High
GABAergic 10 92.20 High High
Inflammation 4 88.24 High High
positron emission tomography 2 83.88 Quite High
rheumatoid arthritis 1 83.72 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 99.84 Very High Very High Very High
Pain 9 98.48 Very High Very High Very High
Rotator Cuff Tears 109 98.44 Very High Very High Very High
Depression 14 98.04 Very High Very High Very High
Schizophrenia 14 89.28 High High
INFLAMMATION 4 88.24 High High
Aging 4 85.40 High High
Rheumatoid Arthritis 1 83.72 Quite High
Age-related Macular Degeneration 1 82.76 Quite High
Disease 19 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overactivity of the LHb may therefore contribute to the pathogenesis of depression by inhibiting the raphe.
Positive_regulation (Overactivity) of Gene_expression (Overactivity) of LHb associated with depression and raphe
1) Confidence 0.42 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0.69 Pain Relevance 0.83
The LHb is responsive to various noxious stimuli in the rat (Benabid & Jeaugey 1989) and the activation of LHb neurons by nociceptive inputs may be responsible for the inhibition of DA neurons of the SNc (Gao et al. 1996).
Positive_regulation (activation) of Gene_expression (neurons) of LHb in neurons associated with nociception
2) Confidence 0.42 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0.25 Pain Relevance 0.39
It is unclear, if this model can be transferred to LHB.
Positive_regulation (transferred) of Gene_expression (transferred) of LHB
3) Confidence 0.30 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936349 Disease Relevance 1.08 Pain Relevance 0.31
Both findings may explain the presence of enhanced MMP 9 expression due to altered LHB mechanical loading in the presence of rotator cuff tears.
Positive_regulation (enhanced) of Gene_expression (expression) of LHB in tears associated with metalloproteinase and rotator cuff tears
4) Confidence 0.22 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.52 Pain Relevance 0.35
We demonstrated that MMP 1 and 9 expression is increased, and MMP 3 expression is decreased in degenerated LHB compared with healthy controls.
Positive_regulation (degenerated) of Gene_expression (degenerated) of LHB associated with metalloproteinase
5) Confidence 0.22 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.72 Pain Relevance 0.25

General Comments

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