INT266287

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Psd) intracellular (Psd) cytoplasm (Psd)
Anatomy Link Frequency
spine 6
cerebellum 2
Psd (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 20 41.52 Quite Low
Neurobehavioral 16 36.24 Quite Low
long-term potentiation 92 5.00 Very Low Very Low Very Low
depression 32 5.00 Very Low Very Low Very Low
imagery 26 5.00 Very Low Very Low Very Low
Pyramidal cell 13 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
nMDA receptor 8 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 31 100.00 Very High Very High Very High
Adhesions 10 95.04 Very High Very High Very High
Convulsion 4 67.84 Quite High
Syndrome 60 64.80 Quite High
Congenital Anomalies 4 64.16 Quite High
Autism 12 50.00 Quite Low
Depression 32 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 24 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 10 5.00 Very Low Very Low Very Low
Schizophrenia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2 in the adult cerebellum induces a parallel expansion of the PSD and a reduction of the presynaptic active zone, suggesting that GluR?
Negative_regulation (reduction) of Gene_expression (expansion) of PSD in cerebellum
1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0.25 Pain Relevance 0
Moreover, there was no expression of full-length Shank3 protein in PSD fractions from Shank3-knockout mice and reduced expression in the heterozygotes, using antibodies which cross-react either with an epitope downstream of the PDZ domain (antibody N69/46; see Figure 1A) (Figure 1C) or with the COOH terminal (data not shown), consistent with haploinsufficiency.
Negative_regulation (reduced) of Gene_expression (expression) of PSD associated with targeted disruption
2) Confidence 0.22 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.32 Pain Relevance 0
Additional studies showed that knockout of Shank1 leads to a decrease in spine number and spine and PSD size, decreased levels of GKAP and Homer, and reduced basal synaptic transmission [18].
Negative_regulation (decrease) of Gene_expression (levels) of PSD in spine associated with targeted disruption
3) Confidence 0.19 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.28 Pain Relevance 0
Additional studies showed that knockout of Shank1 leads to a decrease in spine number and spine and PSD size, decreased levels of GKAP and Homer, and reduced basal synaptic transmission [18].
Negative_regulation (decrease) of Gene_expression (size) of PSD in spine associated with targeted disruption
4) Confidence 0.19 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.28 Pain Relevance 0
Additional studies showed that knockout of Shank1 leads to a decrease in spine number and spine and PSD size, decreased levels of GKAP and Homer, and reduced basal synaptic transmission [18].
Negative_regulation (decreased) of Gene_expression (levels) of PSD in spine associated with targeted disruption
5) Confidence 0.19 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.28 Pain Relevance 0

General Comments

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