INT266292

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Context Info
Confidence 0.51
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 0.73
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a7) transmembrane transport (Slc17a7)
Anatomy Link Frequency
neurons 1
spine 1
Slc17a7 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 40 100.00 Very High Very High Very High
Thalamus 6 95.72 Very High Very High Very High
Cannabinoid 90 91.36 High High
agonist 72 90.92 High High
gABA 48 83.56 Quite High
GABAergic 48 75.28 Quite High
addiction 12 74.04 Quite High
antagonist 42 59.52 Quite High
depression 44 32.80 Quite Low
unmyelinated 6 30.48 Quite Low
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 12 75.48 Quite High
Stress 102 74.48 Quite High
Drug Dependence 12 74.04 Quite High
Body Weight 18 72.96 Quite High
Adhesions 20 65.08 Quite High
Targeted Disruption 12 43.64 Quite Low
Depression 44 32.80 Quite Low
Anxiety Disorder 24 32.20 Quite Low
Increased Venous Pressure Under Development 20 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Each GFP-positive spine was classified as positive or negative if VGluT1 colocalization was present or absent, respectively.
Neg (absent) Localization (colocalization) of VGluT1 in spine
1) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0 Pain Relevance 0
The mean percentage of colocalized area of VGluT1 and GFP over the entire area of GFP in each cell was 0.2 (±0.05; number of cells?
Localization (area) of VGluT1
2) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0.07 Pain Relevance 0.05
Here, we report that CB1 is localized on presynaptic membranes of about 55% of immunopositive synaptic terminals for the vesicular glutamate transporter 1 (vGluT1), which contain abundant spherical, clear synaptic vesicles and make asymmetrical synapses with alBNST neurons.
Localization (localized) of vGluT1 in neurons associated with glutamate
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2810340 Disease Relevance 0.15 Pain Relevance 0.28
A preembedding silver-intensified immunogold method and an immunoperoxidase method were used for the co-localization of CB1 and the vesicular glutamate transporter 1 (vGluT1) in rat alBNST sections.
Localization (localization) of vGluT1 associated with glutamate
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810340 Disease Relevance 0.14 Pain Relevance 0.08
alBNST sections from 3 rats processed for the co-localization of CB1 and vGluT1 with preembedding immunocytochemistry were used for quantitative analysis. 50-µm-thick alBNST sections from each animal showing good and reproducible DAB immunoreaction and silver-intensified gold particles were cut at 80 nm.
Localization (-) of vGluT1
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810340 Disease Relevance 0.15 Pain Relevance 0.13
Double preembedding immunoelectron microscopy was used for the study of the precise localization of CB1 and vGluT1 in the anterolateral BNST (Fig. 2A, C).
Localization (localization) of vGluT1
6) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810340 Disease Relevance 0.07 Pain Relevance 0.03
alBNST sections from 3 rats processed for the co-localization of CB1 and vGluT1 with preembedding immunocytochemistry were used for quantitative analysis. 50-µm-thick alBNST sections from each animal showing good and reproducible DAB immunoreaction and silver-intensified gold particles were cut at 80 nm.
Localization (localization) of vGluT1
7) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810340 Disease Relevance 0.15 Pain Relevance 0.13
Therefore, it is plausible that the vGluT1–and Glu-CB1-KO inhibitory-like synaptic terminals localizing CB1 are overestimated due to the presence of CB1 in excitatory synaptic terminals of non-cortical origin.


Localization (localizing) of vGluT1
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810340 Disease Relevance 0 Pain Relevance 0.28

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