INT266322

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.17
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (S100a4)
S100a4 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 97.28 Very High Very High Very High
Osteoarthritis 4 96.28 Very High Very High Very High
Inflammation 110 44.56 Quite Low
Abeta 24 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
endometriosis 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 62 96.92 Very High Very High Very High
Osteoarthritis 4 96.28 Very High Very High Very High
Injury 12 92.40 High High
Breast Cancer 4 81.92 Quite High
Apoptosis 28 52.08 Quite High
INFLAMMATION 116 44.56 Quite Low
Colon Cancer 2 33.32 Quite Low
Targeted Disruption 8 24.80 Low Low
Disease 14 19.84 Low Low
Noninfiltrating Intraductal Carcinoma 2 5.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S100A4 binds to RAGE, and has been implicated in upregulation of MMP-13 (Matrix Metalloproteinase 13) in osteoarthritis, which leads to tissue remodeling [124].
S100A4 Binding (binds) of associated with metalloproteinase and osteoarthritis
1) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.59 Pain Relevance 0.10
S100A4 binds to the tetramerization domain but not the negative regulatory domain of p53 [104].


S100A4 Binding (binds) of
2) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.58 Pain Relevance 0.08

General Comments

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