INT266326

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Context Info
Confidence 0.65
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.67
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (S100a4)
Anatomy Link Frequency
nerve 1
lung 1
S100a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 2 93.96 High High
metalloproteinase 4 93.08 High High
cytokine 35 87.12 High High
Thoracotomy 12 86.12 High High
Inflammation 133 77.48 Quite High
Inflammatory response 12 55.68 Quite High
fibrosis 18 53.32 Quite High
Abeta 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 12 99.20 Very High Very High Very High
Corneal Neovascularization 12 97.76 Very High Very High Very High
Osteoarthritis 2 93.96 High High
Cancer 35 86.12 High High
Wound Healing 5 82.40 Quite High
Chemical Burns 12 78.80 Quite High
INFLAMMATION 146 77.48 Quite High
Breast Cancer 2 63.68 Quite High
Disease 25 63.60 Quite High
Fibrosis 34 53.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The S100A4 was also upregulated, but to a lesser extent, while S100A3 and S100A13 only slighted increased.
Positive_regulation (upregulated) of S100A4
1) Confidence 0.65 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.08 Pain Relevance 0
Microarray profiling revealed that S100A4, S100A6, S100A8, S100A9, and S100A13 were upregulated in both CorNV models, with S100A8 and S100A9 manifesting the most significant changes compared to the normal animals.
Positive_regulation (upregulated) of S100A4
2) Confidence 0.43 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2994359 Disease Relevance 0.65 Pain Relevance 0.21
After PNY, there was a significant (P < 0.05) increase in the percentage of total nucleated cells that were positive for S100A4, BrdU, or S100A4 in combination with BrdU (Figure 7).
Positive_regulation (positive) of S100A4
3) Confidence 0.40 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.06 Pain Relevance 0.07
Although S100A4 was not up-regulated at the transcriptional level during lung regeneration, this is consistent with regulation via post-transcriptional modulation as seen in other systems [25].
Neg (not) Positive_regulation (up-regulated) of S100A4 in lung
4) Confidence 0.40 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.27 Pain Relevance 0.09
S100A4 is upregulated after nerve tissue injury.
Positive_regulation (upregulated) of S100A4 in nerve associated with injury
5) Confidence 0.21 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.62 Pain Relevance 0.09

General Comments

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