INT266327

Context Info Confidence 0.16 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.23 Pain Relevance 0.33

nucleus (S100a1) cytoplasm (S100a1)

S100a1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 55 99.36 Arthritis 2 97.20 rheumatoid arthritis 1 95.96 Abeta 12 5.00 cytokine 11 5.00 fibrosis 4 5.00 Osteoarthritis 2 5.00 Inflammatory response 2 5.00 metalloproteinase 2 5.00 endometriosis 1 5.00

Disease Link Frequency Relevance Heat Inflammatory Bowel Disease 1 99.92 Autoimmune Disease 1 98.36 INFLAMMATION 58 98.28 Juvenile Chronic Polyarthritis 1 97.20 Arthritis 1 96.36 Rheumatoid Arthritis 1 95.96 Disease 7 94.80 Apoptosis 14 84.04 Wound Healing 1 81.36 Cancer 31 57.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Blockade of the S100-RAGE interaction with soluble RAGE in mice reduced colonic inflammation in IL-10-deficient mice, inhibited arthritis development, and suppressed inflammatory cell infiltration [43,33,32,105].

Negative_regulation (Blockade) of S100 Binding (interaction) of associated with inflammation and arthritis

1) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.23 Pain Relevance 0.33

General Comments

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