INT266330

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.98
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (S100a1) cytoplasm (S100a1)
Anatomy Link Frequency
brain 2
neutrophil 1
S100a1 (Mus musculus)
S100a1 - S100A (1)
Pain Link Frequency Relevance Heat
Inflammation 190 99.40 Very High Very High Very High
ischemia 3 88.48 High High
cytokine 38 84.88 Quite High
endometriosis 3 76.36 Quite High
Osteoarthritis 6 40.80 Quite Low
metalloproteinase 6 39.92 Quite Low
psoriasis 3 21.96 Low Low
Abeta 36 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 199 99.40 Very High Very High Very High
Breast Cancer 6 99.16 Very High Very High Very High
Disease 27 97.16 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 3 96.96 Very High Very High Very High
Anaplastic Astrocytoma 3 90.16 High High
Brain Injury 3 89.60 High High
Cv Unclassified Under Development 3 88.48 High High
Infarction 3 87.76 High High
Stress 39 86.44 High High
Syndrome 3 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extent of upregulation of other detected S100A genes and pro-inflammatory or pro-angiogenic genes was also decreased by neutrophil depletion.
Positive_regulation (upregulation) of S100A (S100A) in neutrophil associated with inflammation
1) Confidence 0.44 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2994359 Disease Relevance 0.48 Pain Relevance 0.22
Although several S100 proteins are upregulated in various forms of breast cancer, S100A7 is strongly up-regulated only in ductal carcinoma in situ [127].
Positive_regulation (upregulated) of S100 associated with breast cancer and noninfiltrating intraductal carcinoma
2) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.74 Pain Relevance 0
S100B, along with S100A1 and S100A6, are the most abundant S100 proteins in the brain of several species including mice and rats.
Positive_regulation (abundant) of S100A1 in brain
3) Confidence 0.22 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.88 Pain Relevance 0.08
S100B, along with S100A1 and S100A6, are the most abundant S100 proteins in the brain of several species including mice and rats.
Positive_regulation (abundant) of S100 in brain
4) Confidence 0.22 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.88 Pain Relevance 0.08

General Comments

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