INT266330

Context Info Confidence 0.44 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.98 Pain Relevance 0.39

nucleus (S100a1) cytoplasm (S100a1)

Anatomy Link Frequency brain 2 neutrophil 1 S100a1 (Mus musculus) S100a1 - S100A (1)

Pain Link Frequency Relevance Heat Inflammation 190 99.40 ischemia 3 88.48 cytokine 38 84.88 endometriosis 3 76.36 Osteoarthritis 6 40.80 metalloproteinase 6 39.92 psoriasis 3 21.96 Abeta 36 5.00 fibrosis 12 5.00 Inflammatory response 6 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 199 99.40 Breast Cancer 6 99.16 Disease 27 97.16 Noninfiltrating Intraductal Carcinoma 3 96.96 Anaplastic Astrocytoma 3 90.16 Brain Injury 3 89.60 Cv Unclassified Under Development 3 88.48 Infarction 3 87.76 Stress 39 86.44 Syndrome 3 84.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The extent of upregulation of other detected S100A genes and pro-inflammatory or pro-angiogenic genes was also decreased by neutrophil depletion.

Positive_regulation (upregulation) of S100A (S100A) in neutrophil associated with inflammation

1) Confidence 0.44 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2994359 Disease Relevance 0.48 Pain Relevance 0.22

Although several S100 proteins are upregulated in various forms of breast cancer, S100A7 is strongly up-regulated only in ductal carcinoma in situ [127].

Positive_regulation (upregulated) of S100 associated with breast cancer and noninfiltrating intraductal carcinoma

2) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.74 Pain Relevance 0

S100B, along with S100A1 and S100A6, are the most abundant S100 proteins in the brain of several species including mice and rats.

Positive_regulation (abundant) of S100A1 in brain

3) Confidence 0.22 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.88 Pain Relevance 0.08

S100B, along with S100A1 and S100A6, are the most abundant S100 proteins in the brain of several species including mice and rats.

Positive_regulation (abundant) of S100 in brain

4) Confidence 0.22 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.88 Pain Relevance 0.08

General Comments

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