INT266342

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.65
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a9) extracellular region (S100a9) plasma membrane (S100a9)
cytoskeleton (S100a9) nucleus (S100a9) cytoplasm (S100a9)
Anatomy Link Frequency
corneas 2
neutrophils 2
S100a9 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 105 92.80 High High
metalloproteinase 2 77.76 Quite High
Osteoarthritis 2 75.76 Quite High
imagery 1 8.16 Low Low
cytokine 21 5.00 Very Low Very Low Very Low
Abeta 12 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chemotherapy-induced Neutropenia 2 100.00 Very High Very High Very High
Cancer 35 99.68 Very High Very High Very High
Chemical Burns 12 99.36 Very High Very High Very High
Corneal Neovascularization 12 94.16 High High
INFLAMMATION 108 92.80 High High
Osteoarthritis 2 75.76 Quite High
Injury 8 73.68 Quite High
Frailty 4 68.28 Quite High
Colon Cancer 1 42.72 Quite Low
Targeted Disruption 6 34.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further showed that depletion of neutrophils decreased S100A8 and S100A9 expression in S-CorNV corneas compared to control S-CorNV corneas (Figure 3).
Negative_regulation (decreased) of Gene_expression (expression) of S100A9 in corneas associated with chemotherapy-induced neutropenia
1) Confidence 0.58 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.49 Pain Relevance 0.11
Depletion of neutrophils abrogated S-CorNV and S100A8 and S100A9 production
Negative_regulation (abrogated) of Gene_expression (production) of S100A9 in neutrophils
2) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.46 Pain Relevance 0.08
Blocking S100A8 and S100A9 expression in the premetastatic stage could prevent this permissive niche from being formed and thus inhibit the migration of tumor cells.


Negative_regulation (Blocking) of Gene_expression (expression) of S100A9 associated with cancer
3) Confidence 0.29 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.69 Pain Relevance 0.13

General Comments

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