INT266354

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.35
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (S100A7) extracellular region (S100A7) endoplasmic reticulum (S100A7)
nucleus (S100A7) cytoplasm (S100A7)
Anatomy Link Frequency
lymphocytes 1
skin 1
melanocytes 1
keratinocytes 1
Langerhans cells 1
S100A7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 154 99.04 Very High Very High Very High
chemokine 23 97.90 Very High Very High Very High
Inflammation 458 97.46 Very High Very High Very High
Osteoarthritis 19 59.32 Quite High
metalloproteinase 14 58.44 Quite High
Inflammatory response 15 53.88 Quite High
psoriasis 70 33.28 Quite Low
Neuropeptide 1 29.24 Quite Low
rheumatoid arthritis 95 16.60 Low Low
Abeta 84 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Sclerosis 34 100.00 Very High Very High Very High
Apoptosis 113 99.64 Very High Very High Very High
Disease 132 98.68 Very High Very High Very High
Injury 45 98.64 Very High Very High Very High
Acne 11 97.84 Very High Very High Very High
INFLAMMATION 481 97.46 Very High Very High Very High
Bacterial Respiratory Disease 7 94.92 High High
Noninfiltrating Intraductal Carcinoma 7 92.56 High High
Breast Cancer 14 89.92 High High
Hypersensitivity 24 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result of TLR stimulation due to P. acnes, pro-inflammatory cytokines, chemokines, antimicrobial lipids [132] and antimicrobial peptides (i.e., cathelicidin, defensin-1, defensin-2, and psoriasin) [134–137], and human B-defensin-2 are produced by these cells [138].
Gene_expression (produced) of psoriasin associated with chemokine, inflammation and cytokine
1) Confidence 0.58 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.19 Pain Relevance 0.44
S100A7 is highly expressed in epidermal hyperproliferative disease and recruits CD4+ lymphocytes and neutrophils [102].
Gene_expression (expressed) of S100A7 in neutrophils associated with disease
2) Confidence 0.31 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.73 Pain Relevance 0
S100A7/S100A7A/S100A15
Gene_expression (/) of S100A7
3) Confidence 0.27 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.55 Pain Relevance 0.06
S100A7/S100A7A/S100A15
Gene_expression (/) of S100A7
4) Confidence 0.27 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.55 Pain Relevance 0.06
Immunohistological studies suggest that S100A7 is produced by keratinocytes surrounding the wound and is released into the wound exudate.
Gene_expression (produced) of S100A7 in keratinocytes associated with injury
5) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.82 Pain Relevance 0.03
Although both S100A7 and S100A7A are expressed in keratinocytes, S100A7A is also expressed in melanocytes and Langerhans cells of the epidermis, and dermal smooth muscle endothelial cells [126].
Gene_expression (expressed) of S100A7 in Langerhans cells
6) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.80 Pain Relevance 0.04
Among differentially expressed genes between SSc and normal control skin were calreticulin (CALR), collagens type V (COL5A2) and type XV (COL15A1), nidogen 2 (NID2), CD14, CD31, VE-cadherin, S100A7, and CD53.
Gene_expression (expressed) of S100A7 in skin associated with systemic sclerosis
7) Confidence 0.18 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.17 Pain Relevance 0.10
S100A7 is highly expressed in epidermal hyperproliferative disease and recruits CD4+ lymphocytes and neutrophils [102].
Gene_expression (expressed) of S100A7 in lymphocytes associated with disease
8) Confidence 0.10 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.73 Pain Relevance 0
Although both S100A7 and S100A7A are expressed in keratinocytes, S100A7A is also expressed in melanocytes and Langerhans cells of the epidermis, and dermal smooth muscle endothelial cells [126].
Gene_expression (expressed) of S100A7 in melanocytes
9) Confidence 0.08 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.80 Pain Relevance 0.04

General Comments

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