INT266383

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.48
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ager, S100b) cytoplasm (Ager, S100b) extracellular region (S100b)
nucleus (S100b) plasma membrane (Ager)
Anatomy Link Frequency
molar 1
Ager (Mus musculus)
S100b (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 84.84 Quite High
diabetic neuropathy 4 80.60 Quite High
ischemia 4 76.64 Quite High
Inflammation 220 68.60 Quite High
cytokine 44 66.04 Quite High
endometriosis 4 45.12 Quite Low
cINOD 4 6.96 Low Low
Abeta 48 5.00 Very Low Very Low Very Low
fibrosis 16 5.00 Very Low Very Low Very Low
Osteoarthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 56 99.28 Very High Very High Very High
Hyperplasia 4 93.04 High High
Stress 52 92.64 High High
Pain 4 84.84 Quite High
Neurodegenerative Disease 12 83.92 Quite High
Diabetes Mellitus 48 83.88 Quite High
Death 24 81.44 Quite High
Diabetic Neuropathy 4 80.60 Quite High
Syndrome 4 78.76 Quite High
Disease 28 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the interaction of RAGE with S100B can produce anti-apoptotic signals, micro-molar concentrations of S100B will produce oxyradicals, inducing apoptosis.
RAGE Binding (interaction) of S100B in molar associated with apoptosis
1) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.97 Pain Relevance 0.22
Upon binding to RAGE and activating intracellular ROS formation, S100B activates the PI 3-kinase/AKT pathway and subsequently the NF?
RAGE Binding (binding) of S100B
2) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.75 Pain Relevance 0.03
S100B binds both the variable (V) and constant (C1) regions of RAGE, and oligomers of S100B bind RAGE more strongly [42,48].
RAGE Binding (binds) of S100B
3) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.89 Pain Relevance 0.04
S100B binds both the variable (V) and constant (C1) regions of RAGE, and oligomers of S100B bind RAGE more strongly [42,48].
RAGE Binding (bind) of S100B
4) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.87 Pain Relevance 0.04

General Comments

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