INT266384

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.32
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ager, S100a6) cytoplasm (Ager, S100a6) cytosol (S100a6)
nuclear envelope (S100a6) extracellular space (Ager) nucleus (S100a6)
Ager (Mus musculus)
S100a6 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 4 71.84 Quite High
metalloproteinase 4 70.96 Quite High
ischemia 2 69.00 Quite High
endometriosis 2 37.48 Quite Low
Inflammation 110 11.64 Low Low
Abeta 24 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 28 100.00 Very High Very High Very High
Breast Cancer 4 97.40 Very High Very High Very High
Stress 26 85.00 Quite High
Hyperplasia 2 82.64 Quite High
Injury 12 79.76 Quite High
Death 12 73.80 Quite High
Neurodegenerative Disease 6 73.52 Quite High
Osteoarthritis 4 71.84 Quite High
Syndrome 2 71.12 Quite High
Disease 14 70.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S100A6 bound significantly to the C2 domain of RAGE, as opposed to the V and/or C1 domains to which most other ligands bind and thus suggests that it might have a discordant function from other RAGE ligands.
RAGE Binding (bound) of S100A6
1) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.50 Pain Relevance 0.07
At equivalent concentrations, S100B increases cell survival while S100A6 induces apoptosis via RAGE interactions, dependant on generation of reactive oxygen species (ROS).
RAGE Binding (interactions) of S100A6 associated with apoptosis
2) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.81 Pain Relevance 0.03

General Comments

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