INT266386

Context Info Confidence 0.03 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.64 Pain Relevance 0.10

cytoplasm (S100a1, Trp53) nucleus (S100a1, Trp53) nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53) enzyme binding (Trp53)

S100a1 (Mus musculus) Trp53 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 2 85.76 Inflammation 110 68.24 rheumatoid arthritis 2 52.80 Arthritis 4 49.44 Abeta 24 5.00 cytokine 22 5.00 fibrosis 8 5.00 Osteoarthritis 4 5.00 Inflammatory response 4 5.00 metalloproteinase 4 5.00

Disease Link Frequency Relevance Heat Apoptosis 28 98.80 Cancer 62 88.40 INFLAMMATION 116 68.24 Disease 14 67.20 Rheumatoid Arthritis 2 52.80 Juvenile Chronic Polyarthritis 2 51.04 Autoimmune Disease 2 47.84 Inflammatory Bowel Disease 2 45.36 Targeted Disruption 8 33.76 Arthritis 2 32.88

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Several S100 proteins bind the tetramerization domain of p53, and some also bind the negative regulatory domain of p53.

S100 Binding (bind) of p53

1) Confidence 0.03 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.54 Pain Relevance 0.06

S100A1 binds to both the tetramerization and negative regulatory domains of p53 [104].

S100A1 Binding (binds) of p53

2) Confidence 0.03 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.10 Pain Relevance 0.04

General Comments

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