INT266386

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (S100a1, Trp53) nucleus (S100a1, Trp53) nucleoplasm (Trp53)
mitochondrion (Trp53) endoplasmic reticulum (Trp53) enzyme binding (Trp53)
S100a1 (Mus musculus)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 2 85.76 High High
Inflammation 110 68.24 Quite High
rheumatoid arthritis 2 52.80 Quite High
Arthritis 4 49.44 Quite Low
Abeta 24 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 28 98.80 Very High Very High Very High
Cancer 62 88.40 High High
INFLAMMATION 116 68.24 Quite High
Disease 14 67.20 Quite High
Rheumatoid Arthritis 2 52.80 Quite High
Juvenile Chronic Polyarthritis 2 51.04 Quite High
Autoimmune Disease 2 47.84 Quite Low
Inflammatory Bowel Disease 2 45.36 Quite Low
Targeted Disruption 8 33.76 Quite Low
Arthritis 2 32.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several S100 proteins bind the tetramerization domain of p53, and some also bind the negative regulatory domain of p53.
S100 Binding (bind) of p53
1) Confidence 0.03 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.54 Pain Relevance 0.06
S100A1 binds to both the tetramerization and negative regulatory domains of p53 [104].
S100A1 Binding (binds) of p53
2) Confidence 0.03 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.10 Pain Relevance 0.04

General Comments

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