INT266387

Context Info Confidence 0.09 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0.05

cytoplasm (S100a1, S100a8) extracellular space (S100a8) extracellular region (S100a8) plasma membrane (S100a8) cytoskeleton (S100a8) nucleus (S100a1)

S100a1 (Mus musculus) S100a8 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 55 58.88 Abeta 12 5.00 cytokine 11 5.00 fibrosis 4 5.00 Osteoarthritis 2 5.00 Inflammatory response 2 5.00 metalloproteinase 2 5.00 Arthritis 2 5.00 endometriosis 1 5.00 Inflammatory marker 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 58 58.88 Cancer 31 58.20 Apoptosis 14 5.00 Stress 13 5.00 Diabetes Mellitus 12 5.00 Adhesions 8 5.00 Lung Cancer 7 5.00 Disease 7 5.00 Death 6 5.00 Injury 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Some form heterodimers with other S100 proteins – for example the S100A8/S100A9 heterodimer is actually the preferred form found within the cell.

S100 Binding (heterodimer) of S100A8

1) Confidence 0.09 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.17 Pain Relevance 0.05

General Comments

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