INT266391

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 5.63
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ager, S100a1) extracellular space (Ager) nucleus (S100a1)
plasma membrane (Ager)
Anatomy Link Frequency
nucleus 3
Ager (Mus musculus)
S100a1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 8 100.00 Very High Very High Very High
Inflammation 440 99.00 Very High Very High Very High
Arthritis 16 97.08 Very High Very High Very High
rheumatoid arthritis 8 95.32 Very High Very High Very High
Abeta 96 5.00 Very Low Very Low Very Low
cytokine 88 5.00 Very Low Very Low Very Low
fibrosis 32 5.00 Very Low Very Low Very Low
Osteoarthritis 16 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
metalloproteinase 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 8 99.28 Very High Very High Very High
INFLAMMATION 464 99.00 Very High Very High Very High
Autoimmune Disease 8 97.72 Very High Very High Very High
Arthritis 8 97.08 Very High Very High Very High
Juvenile Chronic Polyarthritis 8 96.56 Very High Very High Very High
Rheumatoid Arthritis 8 95.32 Very High Very High Very High
Wound Healing 8 94.72 High High
Disease 56 94.16 High High
Apoptosis 112 90.60 High High
Cancer 248 57.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is still some debate if S100A1 binds to RAGE, although recent work with PET Imaging of Fluorine-18 labeled S100A1 administered to mice indicates that it co-localizes with RAGE [117].
RAGE Binding (binds) of S100A1 associated with imagery
1) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.15 Pain Relevance 0.05
One area that has not received much attention is the possibility of S100 binding to a soluble RAGE in the cytosol or nucleus (as opposed to extracellular soluble RAGE).


RAGE Binding (binding) of S100 in nucleus
2) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.70 Pain Relevance 0.22
There is still some debate if S100A1 binds to RAGE, although recent work with PET Imaging of Fluorine-18 labeled S100A1 administered to mice indicates that it co-localizes with RAGE [117].
RAGE Binding (binds) of S100A1 associated with imagery
3) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.21 Pain Relevance 0.05
One area that has not received much attention is the possibility of S100 binding to a soluble RAGE in the cytosol or nucleus (as opposed to extracellular soluble RAGE).


RAGE Binding (binding) of S100 in nucleus
4) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.70 Pain Relevance 0.22
One area that has not received much attention is the possibility of S100 binding to a soluble RAGE in the cytosol or nucleus (as opposed to extracellular soluble RAGE).


RAGE Binding (binding) of S100 in nucleus
5) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.70 Pain Relevance 0.22
There are several important questions that need to be addressed when examining proposed S100-RAGE interactions: Does this interaction occur in vivo in addition to in vitro?
RAGE Binding (interactions) of S100
6) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.98 Pain Relevance 0.29
Blockade of the S100-RAGE interaction with soluble RAGE in mice reduced colonic inflammation in IL-10-deficient mice, inhibited arthritis development, and suppressed inflammatory cell infiltration [43,33,32,105].
RAGE Binding (interaction) of S100 associated with inflammation and arthritis
7) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.23 Pain Relevance 0.33
There are several important questions that need to be addressed when examining proposed S100-RAGE interactions: Does this interaction occur in vivo in addition to in vitro?
RAGE Binding (interactions) of S100
8) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.98 Pain Relevance 0.29

General Comments

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