INT266396

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 0.10

extracellular space (Ager) nucleus (S100a4) plasma membrane (Ager) cytoplasm (Ager)

Ager (Mus musculus) S100a4 (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 2 97.60 Osteoarthritis 2 96.60 Inflammation 55 44.56 Abeta 12 5.00 cytokine 11 5.00 fibrosis 4 5.00 Inflammatory response 2 5.00 Arthritis 2 5.00 endometriosis 1 5.00 Inflammatory marker 1 5.00

Disease Link Frequency Relevance Heat Cancer 31 96.92 Osteoarthritis 2 96.60 Injury 6 76.72 INFLAMMATION 58 44.56 Breast Cancer 2 42.00 Colon Cancer 1 33.32 Targeted Disruption 4 24.80 Apoptosis 14 17.84 Stress 13 5.00 Diabetes Mellitus 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

S100A4 binds to RAGE, and has been implicated in upregulation of MMP-13 (Matrix Metalloproteinase 13) in osteoarthritis, which leads to tissue remodeling [124].

RAGE Binding (binds) of S100A4 associated with metalloproteinase and osteoarthritis

1) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.59 Pain Relevance 0.10

General Comments

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