INT26640

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Context Info
Confidence 0.35
First Reported 1987
Last Reported 2009
Negated 6
Speculated 3
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 3.94
Pain Relevance 7.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pigm)
Anatomy Link Frequency
hippocampus 4
brain 2
STR 2
supraoptic nucleus 1
caudate putamen 1
Pigm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 8 100.00 Very High Very High Very High
aspirin 6 100.00 Very High Very High Very High
Hippocampus 38 99.88 Very High Very High Very High
fluoxetine 2 99.84 Very High Very High Very High
anesthesia 4 99.74 Very High Very High Very High
Morphine 13 99.62 Very High Very High Very High
tricyclic antidepressant 8 99.62 Very High Very High Very High
antagonist 12 99.40 Very High Very High Very High
agonist 18 99.10 Very High Very High Very High
Desipramine 10 98.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 17 100.00 Very High Very High Very High
Fatigue 5 98.16 Very High Very High Very High
Ganglion Cysts 8 96.12 Very High Very High Very High
Depression 2 95.36 Very High Very High Very High
Shock 12 95.04 Very High Very High Very High
Nociception 4 91.96 High High
Targeted Disruption 1 87.12 High High
Hypersensitivity 1 84.76 Quite High
Neuropathic Pain 3 81.72 Quite High
Acute-phase Reaction 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of deep prepyriform cortex (DPC) kindling on the levels of prodynorphin mRNA (DYN mRNA) in rat hippocampus and striatum was examined under two different stimulation paradigms.
Spec (examined) Regulation (effect) of DYN mRNA in striatum associated with hippocampus
1) Confidence 0.35 Published 1989 Journal Brain Res. Section Abstract Doc Link 2776033 Disease Relevance 0.15 Pain Relevance 0.12
Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant.
Regulation (regulation) of GRII mRNA associated with tricyclic antidepressant
2) Confidence 0.33 Published 1995 Journal Brain Res. Section Title Doc Link 7583316 Disease Relevance 0.10 Pain Relevance 0.58
In contrast to DMI, the non-tricyclic antidepressant fluoxetine had no effect on GRII mRNA.
Neg (no) Regulation (effect) of GRII mRNA associated with desipramine, tricyclic antidepressant and fluoxetine
3) Confidence 0.33 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583316 Disease Relevance 0.08 Pain Relevance 0.61
In contrast, i.t. morphine caused a biphasic alteration in glial fibrillary acidic protein (GFAP) and integrin alpha M mRNA.
Regulation (alteration) of M mRNA associated with morphine
4) Confidence 0.24 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15743926 Disease Relevance 0.31 Pain Relevance 1.55
The effect of deep prepyriform cortex (DPC) kindling on the levels of prodynorphin mRNA (DYN mRNA) in rat hippocampus and striatum was examined under two different stimulation paradigms.
Spec (examined) Regulation (effect) of DYN mRNA in hippocampus associated with hippocampus
5) Confidence 0.12 Published 1989 Journal Brain Res. Section Abstract Doc Link 2776033 Disease Relevance 0.15 Pain Relevance 0.12
I, a biphasic change in the DYN mRNA level was found in the hippocampus, with an initial 49% decrease at 0.5 h followed by a 51% increase at 6 h after a single ECS.
Regulation (change) of DYN mRNA in hippocampus associated with shock and hippocampus
6) Confidence 0.06 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2770451 Disease Relevance 0.85 Pain Relevance 0.21
Regulation of preprosomatostatin mRNA and tyrosine hydroxylase mRNA were examined in sympathetic neurons of the rat superior cervical ganglion (SCG).
Regulation (Regulation) of preprosomatostatin mRNA in neurons associated with ganglion cysts
7) Confidence 0.06 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2564623 Disease Relevance 0.37 Pain Relevance 0.08
High basal levels of NGFI-A mRNA were present in cortical layers IV and VI, hippocampal CA1, piriform cortex, amygdala and caudate putamen. alpha 1-AR agonist and antagonist treatment had essentially no effect on IEG mRNA, despite producing characteristic behavioral and peripheral effects at the doses used.
Neg (no) Regulation (effect) of IEG mRNA in caudate putamen associated with antagonist, agonist and amygdala
8) Confidence 0.05 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7723621 Disease Relevance 0 Pain Relevance 0.73
Differences in the effects of membrane depolarization on levels of preprosomatostatin mRNA and tyrosine hydroxylase mRNA in rat sympathetic neurons in vivo and in culture.
Regulation (effects) of preprosomatostatin mRNA in sympathetic
9) Confidence 0.04 Published 1989 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 2564623 Disease Relevance 0.36 Pain Relevance 0.11
To determine the possible role of cyclooxygenase/lipoxygenase pathway in the regulation of proenkephalin (proENK) and prodynorphin (proDYN) gene expression induced by kainic acid (KA) in rat hippocampus, the effects of esculetin, aspirin, or phenidone on the seizure activity, proENK and proDYN mRNA levels, and the level of fos-related antigene (Fra) protein induced by KA in rat hippocampus were studied.
Regulation (effects) of proDYN mRNA in hippocampus associated with aspirin, convulsion and hippocampus
10) Confidence 0.04 Published 1998 Journal Brain Res. Section Abstract Doc Link 9519284 Disease Relevance 0.25 Pain Relevance 0.27
Prolonged effects of polyriboinosinic:polyribocytidylic acid on spontaneous running wheel activity and brain interferon-alpha mRNA in rats: a model for immunologically induced fatigue.
Regulation (effects) of mRNA in brain associated with fatigue
11) Confidence 0.03 Published 2003 Journal Neuroscience Section Title Doc Link 12895523 Disease Relevance 0.31 Pain Relevance 0.12
High basal levels of NGFI-A mRNA were present in cortical layers IV and VI, hippocampal CA1, piriform cortex, amygdala and caudate putamen. alpha 1-AR agonist and antagonist treatment had essentially no effect on IEG mRNA, despite producing characteristic behavioral and peripheral effects at the doses used.
Neg (no) Regulation (effect) of IEG mRNA in amygdala associated with antagonist, agonist and amygdala
12) Confidence 0.02 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7723621 Disease Relevance 0 Pain Relevance 0.73
High basal levels of NGFI-A mRNA were present in cortical layers IV and VI, hippocampal CA1, piriform cortex, amygdala and caudate putamen. alpha 1-AR agonist and antagonist treatment had essentially no effect on IEG mRNA, despite producing characteristic behavioral and peripheral effects at the doses used.
Neg (no) Regulation (effect) of IEG mRNA in piriform cortex associated with antagonist, agonist and amygdala
13) Confidence 0.02 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7723621 Disease Relevance 0 Pain Relevance 0.73
CONCLUSIONS: Distinct alterations of D2R and DYN mRNA levels in SN and Acb/STR, respectively, strengthen the evidence implicating pre- and postsynaptic changes in augmented locomotor sensitization to U69593/QNP cotreatment.
Regulation (alterations) of DYN mRNA in STR
14) Confidence 0.01 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17619861 Disease Relevance 0 Pain Relevance 0
We have assessed (1) AVP levels in plasma and the changes of eGFP mRNA and AVP heteronuclear RNA (hnRNA) in the supraoptic nucleus (SON) and the paraventricular nucleus (PVN) using in situ hybridization histochemistry, (2) gene expression changes in distinct magnocellular and parvocellular divisions of the PVN, (3) eGFP fluorescence in the SON, the PVN, the median eminence (ME), and the posterior pituitary gland (PP).
Regulation (changes) of eGFP mRNA in supraoptic nucleus
15) Confidence 0.01 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19846706 Disease Relevance 0.33 Pain Relevance 0
Differential regulation of neuropeptide and proto-oncogene mRNA content in the hippocampus following recurrent seizures.
Regulation (regulation) of mRNA in hippocampus associated with anesthesia, convulsion, neuropeptide and hippocampus
16) Confidence 0.01 Published 1987 Journal Brain Res. Section Title Doc Link 3427445 Disease Relevance 0.30 Pain Relevance 0.42
It was determined that the hilus lesion led to a dramatic (18-fold) increase in the content of preproenkephalin mRNA in the entorhinal cortex whereas only a modest increase in preproneuropeptide Y mRNA content and no change in preprocholecystokinin mRNA was detected in this same brain region.
Neg (no) Regulation (change) of mRNA in brain
17) Confidence 0.01 Published 1987 Journal Brain Res. Section Abstract Doc Link 3427445 Disease Relevance 0.31 Pain Relevance 0.39
The elevations of both proENK and proDYN mRNA levels induced by KA was effectively inhibited by pre-administration of L-ARG (400 mg/kg, i.p.), but was not affected by pre-treatment with L-NAME (200 mg/kg, i.p.).
Neg (not) Regulation (affected) of proDYN mRNA
18) Confidence 0.01 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.08
CONCLUSIONS: Distinct alterations of D2R and DYN mRNA levels in SN and Acb/STR, respectively, strengthen the evidence implicating pre- and postsynaptic changes in augmented locomotor sensitization to U69593/QNP cotreatment.
Regulation (alterations) of DYN mRNA in Acb
19) Confidence 0.00 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17619861 Disease Relevance 0 Pain Relevance 0
In addition, the effect of endotoxin treatment on selected UGT mRNA levels in the liver and the kidney was also investigated.
Spec (investigated) Regulation (effect) of mRNA in kidney
20) Confidence 0.00 Published 2008 Journal Drug Metab Lett Section Abstract Doc Link 19356101 Disease Relevance 0.07 Pain Relevance 0.15

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