INT266406

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.34
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (APP, Ager) plasma membrane (APP, Ager) Golgi apparatus (APP)
extracellular matrix organization (APP) DNA binding (APP) cytosol (APP)
Anatomy Link Frequency
neurons 1
microglial cells 1
APP (Homo sapiens)
Ager (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 36 100.00 Very High Very High Very High
cINOD 3 57.56 Quite High
Inflammation 165 57.00 Quite High
fibrosis 12 6.80 Low Low
cytokine 33 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
endometriosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 3 97.00 Very High Very High Very High
Drug Induced Neurotoxicity 3 96.48 Very High Very High Very High
Amyloid Plaque 3 93.72 High High
Stress 39 91.92 High High
Alzheimer's Dementia 6 89.32 High High
Neuroblastoma 3 88.40 High High
Death 18 82.56 Quite High
INFLAMMATION 174 57.00 Quite High
Cancer 93 52.08 Quite High
Drug Hypersensitivity 3 48.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The V and C1 domains of RAGE bind to Abeta oligomers and aggregates (respectively), and blocking these will prevent Abeta-induced neurotoxicity [156].
Abeta Binding (bind) of RAGE associated with drug induced neurotoxicity and abeta
1) Confidence 0.00 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.89 Pain Relevance 0.51
Abeta binds to RAGE on neurons and microglial cells [152].
Abeta Binding (binds) of RAGE in microglial cells associated with abeta
2) Confidence 0.00 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.73 Pain Relevance 0.53
Abeta binds to RAGE on neurons and microglial cells [152].
Abeta Binding (binds) of RAGE in neurons associated with abeta
3) Confidence 0.00 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.73 Pain Relevance 0.53

General Comments

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