INT266408

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.57
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (HMGB1, Ager) extracellular space (HMGB1, Ager) nucleoplasm (HMGB1)
DNA binding (HMGB1) extracellular region (HMGB1) nucleolus (HMGB1)
Anatomy Link Frequency
neuronal 2
nucleus 1
HMGB1 (Homo sapiens)
Ager (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 44 99.68 Very High Very High Very High
Pain 4 96.44 Very High Very High Very High
diabetic neuropathy 4 92.20 High High
inflammatory 220 89.92 High High
Abeta 48 5.00 Very Low Very Low Very Low
Fibrosis 16 5.00 Very Low Very Low Very Low
osteoarthritis 8 5.00 Very Low Very Low Very Low
inflammatory response 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 4 96.44 Very High Very High Very High
Diabetes Mellitus 48 95.48 Very High Very High Very High
Diabetic Neuropathy 4 92.20 High High
INFLAMMATION 232 89.92 High High
Increased Venous Pressure Under Development 16 88.64 High High
Stress 52 79.64 Quite High
Apoptosis 56 78.56 Quite High
Necrosis 12 76.76 Quite High
Cancer 124 76.40 Quite High
Reperfusion Injury 4 74.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction between HMGB1 and RAGE in vitro promotes neurite outgrowth of cortical cells, suggesting a potential role of RAGE as a mediator in neuronal development [166].
HMGB1 Binding (interaction) of RAGE in neuronal
1) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.10 Pain Relevance 0.26
The interaction between HMGB1 and RAGE in vitro promotes neurite outgrowth of cortical cells, suggesting a potential role of RAGE as a mediator in neuronal development [166].
HMGB1 Binding (interaction) of RAGE in neuronal
2) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.10 Pain Relevance 0.26
HMGB1 binding to RAGE is enhanced with CpG DNA.
HMGB1 Binding (binding) of RAGE
3) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.31 Pain Relevance 0.21
Since HMGB1 translocates between the nucleus and cytosol, there is a possibility that it could bind to soluble RAGE in the cytosol and thereby play a role in regulating its activity.


HMGB1 Binding (bind) of RAGE in nucleus
4) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

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