INT26641

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Context Info
Confidence 0.20
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.61
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Fdft1) endoplasmic reticulum (Fdft1) transferase activity, transferring alkyl or aryl (other than methyl) groups (Fdft1)
Anatomy Link Frequency
spinal 1
neurons 1
Fdft1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 46 100.00 Very High Very High Very High
substance P 58 98.88 Very High Very High Very High
Calcitonin gene-related peptide 64 98.80 Very High Very High Very High
sodium channel 1 97.36 Very High Very High Very High
spinal dorsal horn 22 96.88 Very High Very High Very High
Neuropeptide 18 96.00 Very High Very High Very High
dexamethasone 86 95.48 Very High Very High Very High
tetrodotoxin 2 95.44 Very High Very High Very High
antagonist 1 92.76 High High
corticosteroid 66 92.56 High High
Disease Link Frequency Relevance Heat
Colon Cancer 4 99.92 Very High Very High Very High
Disease 4 94.08 High High
Nociception 50 90.56 High High
Pain 46 89.16 High High
Ganglion Cysts 4 87.64 High High
Urological Neuroanatomy 6 64.72 Quite High
Stress 24 42.32 Quite Low
Polycystic Ovary Syndrome 14 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the induction of SS mRNA expression by K+ involves the modulation of calcium ion channels.
Gene_expression (expression) of SS mRNA
1) Confidence 0.20 Published 1993 Journal J Pediatr Endocrinol Section Abstract Doc Link 7920985 Disease Relevance 0 Pain Relevance 0.30
Potassium- or veratridine-induced membrane depolarization of cultured neonatal sympathetic neurons decreased levels of SS mRNA but elevated levels of TH mRNA.
Gene_expression (levels) of SS mRNA in neurons
2) Confidence 0.03 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2564623 Disease Relevance 0.34 Pain Relevance 0.14
Contrary to CGRP, SP and GABAB2, no effect of GC was observed on the spinal levels of SS.
Gene_expression (levels) of SS in spinal associated with somatostatin, substance p and calcitonin gene-related peptide
3) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.41 Pain Relevance 1.32
The expression of SS remained unaltered throughout the experimental period.


Gene_expression (expression) of SS associated with somatostatin
4) Confidence 0.03 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2727498 Disease Relevance 0.31 Pain Relevance 1.32
Farnesyl transferase inhibition, inhibition of the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor (VEGF) are undergoing evaluation in advanced disease.
Gene_expression (inhibition) of Farnesyl transferase associated with disease
5) Confidence 0.01 Published 2002 Journal Eur. J. Cancer Section Abstract Doc Link 11978525 Disease Relevance 0.55 Pain Relevance 0.06

General Comments

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