INT266417

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.86
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (TGM2, S100a11) mitochondrion (TGM2) nucleus (S100a11)
plasma membrane (TGM2) transferase activity, transferring acyl groups (TGM2)
Anatomy Link Frequency
chondrocyte 1
TGM2 (Homo sapiens)
S100a11 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 55 93.20 High High
Osteoarthritis 2 91.12 High High
psoriasis 1 41.68 Quite Low
Abeta 12 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 1 95.40 Very High Very High Very High
INFLAMMATION 58 93.20 High High
Osteoarthritis 2 91.12 High High
Cancer 31 84.04 Quite High
Psoriasis 2 70.40 Quite High
Bacterial Respiratory Disease 1 60.28 Quite High
Hypersensitivity 3 59.12 Quite High
Injury 6 58.80 Quite High
Noninfiltrating Intraductal Carcinoma 1 47.84 Quite Low
Breast Cancer 2 45.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extracellular S100A11 is dimerized by transglutaminase 2, and this covalent homodimer acquires the capacity to signal through the p38 MAPK pathway, accelerate chondrocyte hypertrophy and matrix catabolism, and thereby couples inflammation with chondrocyte activation to promote osteoarthritis progression [131].


transglutaminase 2 Binding (dimerized) of S100A11 in chondrocyte associated with hypertrophy, inflammation and osteoarthritis
1) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.86 Pain Relevance 0.16

General Comments

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