INT266419

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.37
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (HMGB1, Ager) extracellular space (HMGB1, Ager) nucleoplasm (HMGB1)
DNA binding (HMGB1) extracellular region (HMGB1) nucleolus (HMGB1)
HMGB1 (Homo sapiens)
Ager (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 33 97.76 Very High Very High Very High
Inflammation 165 97.32 Very High Very High Very High
Inflammatory stimuli 3 68.72 Quite High
Inflammatory marker 3 44.88 Quite Low
Inflammatory response 6 28.52 Quite Low
Abeta 36 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 174 97.32 Very High Very High Very High
Charcot Marie Tooth Disease 6 95.20 Very High Very High Very High
Adhesions 24 93.20 High High
Diabetes Mellitus 36 86.96 High High
Disease 21 81.36 Quite High
Stress 39 77.72 Quite High
Myeloid Leukemia 12 54.64 Quite High
Cancer 93 50.00 Quite Low
Albuminuria 3 49.32 Quite Low
Targeted Disruption 12 46.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HMGB1's ability to activate RAGE may result more from its ability to form a complex with other pro-inflammatory molecules, with this complex subsequently activating RAGE [93].
HMGB1 Positive_regulation (activate) of RAGE associated with inflammation
1) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.36 Pain Relevance 0.24
HMG (High Mobility Group) proteins are very basic, nuclear, non-histone chromosomal proteins of which HMGB1 is the only member that has been shown to activate RAGE.
HMGB1 Positive_regulation (activate) of RAGE
2) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.11 Pain Relevance 0.03
For example, HMGB1, S100B, Mac-1, and S100A6 activate RAGE through distinct signal transduction pathways [42,43].
HMGB1 Positive_regulation (activate) of RAGE
3) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.90 Pain Relevance 0.10

General Comments

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