INT266419

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.37 Pain Relevance 0.37

cytoplasm (HMGB1, Ager) extracellular space (HMGB1, Ager) nucleoplasm (HMGB1) DNA binding (HMGB1) extracellular region (HMGB1) nucleolus (HMGB1)

HMGB1 (Homo sapiens) Ager (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 33 97.76 Inflammation 165 97.32 Inflammatory stimuli 3 68.72 Inflammatory marker 3 44.88 Inflammatory response 6 28.52 Abeta 36 5.00 fibrosis 12 5.00 Osteoarthritis 6 5.00 metalloproteinase 6 5.00 Arthritis 6 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 174 97.32 Charcot Marie Tooth Disease 6 95.20 Adhesions 24 93.20 Diabetes Mellitus 36 86.96 Disease 21 81.36 Stress 39 77.72 Myeloid Leukemia 12 54.64 Cancer 93 50.00 Albuminuria 3 49.32 Targeted Disruption 12 46.16

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HMGB1's ability to activate RAGE may result more from its ability to form a complex with other pro-inflammatory molecules, with this complex subsequently activating RAGE [93].

HMGB1 Positive_regulation (activate) of RAGE associated with inflammation

1) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.36 Pain Relevance 0.24

HMG (High Mobility Group) proteins are very basic, nuclear, non-histone chromosomal proteins of which HMGB1 is the only member that has been shown to activate RAGE.

HMGB1 Positive_regulation (activate) of RAGE

2) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.11 Pain Relevance 0.03

For example, HMGB1, S100B, Mac-1, and S100A6 activate RAGE through distinct signal transduction pathways [42,43].

HMGB1 Positive_regulation (activate) of RAGE

3) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.90 Pain Relevance 0.10

General Comments

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