INT26643

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.26
Pain Relevance 7.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
eyes 2
neurons 2
Brain 2
locus coeruleus 2
olfactory bulb 2
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 35 100.00 Very High Very High Very High
Ventral tegmentum 17 100.00 Very High Very High Very High
Catecholamine 6 100.00 Very High Very High Very High
Hippocampus 5 100.00 Very High Very High Very High
Nicotine 4 100.00 Very High Very High Very High
Glutamate receptor 1 100.00 Very High Very High Very High
Clonidine 9 99.88 Very High Very High Very High
Locus ceruleus 4 99.84 Very High Very High Very High
sodium channel 1 99.84 Very High Very High Very High
Endogenous opioid 3 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Weight Loss 1 92.56 High High
Substance Withdrawal Syndrome 3 91.88 High High
Diarrhoea 1 90.16 High High
Pheochromocytoma 2 89.60 High High
Ganglion Cysts 4 88.04 High High
Bordatella Infection 1 87.28 High High
Morphine Dependence 2 81.12 Quite High
Drug Dependence 2 64.00 Quite High
Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the sympathectomised eyes there was a marked depletion of TH and increase in CGRP immunoreactivity while in tissue subjected to sensory denervation the reverse was found, raised presence of TH and absence of CGRP-immunostaining.
Negative_regulation (depletion) of Positive_regulation (increase) of TH in eyes
1) Confidence 0.59 Published 1988 Journal Curr. Eye Res. Section Abstract Doc Link 2903010 Disease Relevance 0 Pain Relevance 0.15
The induction of tyrosine hydroxylase after morphine exposure was also reduced in locus coeruleus when agmatine was administered along with morphine.
Negative_regulation (reduced) of Positive_regulation (induction) of tyrosine hydroxylase in locus coeruleus associated with locus ceruleus and morphine
2) Confidence 0.59 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15541421 Disease Relevance 0.42 Pain Relevance 1.58
Clonidine also blocked the increases in tyrosine hydroxylase activity seen in the adrenal and locus ceruleus during withdrawal.
Negative_regulation (blocked) of Positive_regulation (increases) of tyrosine hydroxylase associated with locus ceruleus, withdrawal and clonidine
3) Confidence 0.57 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 4039756 Disease Relevance 0.18 Pain Relevance 1.43
Potassium- or veratridine-induced membrane depolarization of cultured neonatal sympathetic neurons decreased levels of SS mRNA but elevated levels of TH mRNA.
Negative_regulation (decreased) of Positive_regulation (elevated) of TH mRNA in neurons
4) Confidence 0.43 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2564623 Disease Relevance 0.35 Pain Relevance 0.15
By using nuclear run-on assays, we found that transcription increased for both endogenous TH and ppEnk genes, even at time points and concentrations when reduced steady-state levels of TH mRNA were observed.
Negative_regulation (reduced) of Positive_regulation (levels) of TH mRNA
5) Confidence 0.43 Published 2007 Journal Brain Res. Section Abstract Doc Link 17174279 Disease Relevance 0 Pain Relevance 0.18
With naltrexone treatment, ethanol-induced increase in the TH mRNA level was reduced in the VTA.
Negative_regulation (reduced) of Positive_regulation (increase) of TH mRNA
6) Confidence 0.42 Published 2005 Journal Alcohol Alcohol. Section Body Doc Link 15897221 Disease Relevance 0 Pain Relevance 0
As in the rat, MTZ produced a dose-dependent induction of c-fos mRNA in the hamster adrenal and hippocampus together with an increase in adrenal TH mRNA.
Negative_regulation (produced) of Positive_regulation (increase) of TH mRNA in hippocampus associated with hippocampus
7) Confidence 0.41 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7501282 Disease Relevance 0 Pain Relevance 0.22
These data suggest that endogenous opioids selectively inhibit KCl-stimulated Ca2+ entry and thus TH induction in olfactory bulb cell cultures.
Negative_regulation (inhibit) of Positive_regulation (induction) of TH in olfactory bulb associated with endogenous opioid
8) Confidence 0.37 Published 1994 Journal Brain Res. Section Abstract Doc Link 7834330 Disease Relevance 0 Pain Relevance 0.76
Brain-derived neurotrophic factor, which by itself tended to decrease tyrosine hydroxylase levels in the ventral tegmental area, prevented the characteristic increase in tyrosine hydroxylase following morphine and cocaine exposure and reversed the increase in rats pretreated with morphine.
Negative_regulation (prevented) of Positive_regulation (increase) of tyrosine hydroxylase in Brain associated with ventral tegmentum, cocaine and morphine
9) Confidence 0.26 Published 1995 Journal Neuroscience Section Abstract Doc Link 8545003 Disease Relevance 0 Pain Relevance 1.23
Pre-treatment with the MAPK specific inhibitor (U0126) or the adenylate cyclase inhibitor dideoxyadenosine (ddA) abolished the butyrate-induced: (i) accumulation of TH mRNA, (ii) the phosphorylation of ERK1/2 as well as (iii) CREB phosphorylation.
Negative_regulation (abolished) of Positive_regulation (accumulation) of TH mRNA
10) Confidence 0.22 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0
U-69593 (a kappa-opioid agonist: >/=100 nM) significantly inhibited the nicotine-induced increase of tyrosine hydroxylase (TH, a rate-limiting enzyme in biosynthesis of catecholamine) enzyme activity and TH mRNA levels.
Negative_regulation (inhibited) of Positive_regulation (increase) of TH mRNA associated with mu agonist, catecholamine and nicotine
11) Confidence 0.17 Published 2000 Journal FEBS Lett. Section Abstract Doc Link 10908734 Disease Relevance 0.25 Pain Relevance 0.86
Biochemical traits related to morphine's sensitizing effects were altered by intra-VTA anti-FGF-1 because morphine-induced upregulation of both tyrosine hydroxylase (TH) and N-methyl d-aspartate glutamate receptor 1 (NMDAR1) in the VTA was blocked after anti-FGF-1.
Negative_regulation (blocked) of Positive_regulation (upregulation) of tyrosine hydroxylase associated with ventral tegmentum, glutamate receptor and morphine
12) Confidence 0.03 Published 2010 Journal Neuroscience Section Abstract Doc Link 19819303 Disease Relevance 0.06 Pain Relevance 1.20

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