INT266506

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
rsm1 (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 38 95.20 Very High Very High Very High
Schistosomiasis 66 92.12 High High
Malaria 14 92.12 High High
Infection 40 89.80 High High
Body Weight 2 83.24 Quite High
Syndrome 38 55.88 Quite High
Chronic Disease 8 50.32 Quite High
Neglected Diseases 1 35.32 Quite Low
Parasitic Infection 7 27.20 Quite Low
Eosinophilia 10 23.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in mice sacrificed five days after treatment the Schistosoma CFPD concentration in pooled plasma was considerably increased against the group that was sacrificed immediately before treatment (899.23 vs 128.27 target gene copies per mL).
Positive_regulation (increased) of Schistosoma in plasma
1) Confidence 0.48 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2667260 Disease Relevance 0.36 Pain Relevance 0
Consistent with the hypothesis that circulating Schistosoma DNA stemmed from decaying parasites, a marked increase of CFPD concentration was observed in plasma of mice sampled short after initiation of therapy.
Positive_regulation (circulating) of Schistosoma in plasma
2) Confidence 0.35 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2667260 Disease Relevance 0.52 Pain Relevance 0
From the limited number of studies (in vivo & in vitro) conducted on Schistosoma spp with artemisinin derivatives, higher cure rates were obtained when artesunate was used in combination with praziquantel in comparison to cure rates of artemether or artesunate alone [9], [10], [11].
Positive_regulation (conducted) of Schistosoma
3) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749939 Disease Relevance 0.42 Pain Relevance 0

General Comments

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