INT266535

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Context Info
Confidence 0.79
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 0.63
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUP) cell morphogenesis (JUP) structural molecule activity (JUP)
plasma membrane (JUP) cytoskeleton (JUP) nucleus (JUP)
Anatomy Link Frequency
neurons 1
bladder 1
T24 1
JUP (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 22 99.84 Very High Very High Very High
interstitial cystitis 36 5.00 Very Low Very Low Very Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
depression 10 5.00 Very Low Very Low Very Low
Glutamate receptor 8 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 192 99.68 Very High Very High Very High
Adhesions 6 89.32 High High
Cancer 42 55.28 Quite High
Carcinoma 12 46.32 Quite Low
Interstitial Cystitis 36 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 24 5.00 Very Low Very Low Very Low
Metastasis 18 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Depression 10 5.00 Very Low Very Low Very Low
Retinoblastoma 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin mutant defective in Ser-447 phosphorylation showed enhanced ability to promote dendrite branching in cultured neurons.
Phosphorylation (phosphorylation) of catenin in neurons
1) Confidence 0.79 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Abstract Doc Link PMC2667352 Disease Relevance 0.09 Pain Relevance 0
-catenin phosphorylation in T24 cells.
Phosphorylation (phosphorylation) of catenin in T24
2) Confidence 0.79 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.06 Pain Relevance 0
-catenin phosphorylation in T24 bladder carcinoma cells.
Phosphorylation (phosphorylation) of catenin in bladder associated with bladder cancer
3) Confidence 0.79 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.10 Pain Relevance 0
-catenin (serine 45/threonine 41) phosphorylation, but increased ?
Phosphorylation (phosphorylation) of catenin
4) Confidence 0.79 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.07 Pain Relevance 0
-catenin phosphorylation were apparent following APF treatment of nontransfected cells when antibodies against phosphoserine 33, 37 and threonine 41 (ser33,37/thr41) sites were used, there was no apparent change in total cell ?
Phosphorylation (phosphorylation) of catenin
5) Confidence 0.79 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.06 Pain Relevance 0
-catenin phosphorylation in response to APF, they also provide additional evidence that APF may mediate its profound effects on cell proliferation and gene expression via means other than (or in addition to) regulation of canonical Wnt/frizzled signaling pathways.


Phosphorylation (phosphorylation) of catenin
6) Confidence 0.79 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.19 Pain Relevance 0
-catenin (serine 33, 37/threonine 41) phosphorylation, in response to APF
Phosphorylation (phosphorylation) of catenin
7) Confidence 0.79 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.07 Pain Relevance 0
-catenin Ser-447 phosphorylation by TTX and bicuculline is bidirectional and qualitatively similar to that of PSD-95 Ser-295 (55) consistent with both of these sites being targets of JNK MAPK.
Phosphorylation (phosphorylation) of catenin associated with tetrodotoxin
8) Confidence 0.61 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0.49

General Comments

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