INT266542

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.19
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Olr447)
Anatomy Link Frequency
neurons 2
dendrite 1
Olr447 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 77 99.84 Very High Very High Very High
depression 35 5.00 Very Low Very Low Very Low
Glutamate receptor 28 5.00 Very Low Very Low Very Low
Glutamate 21 5.00 Very Low Very Low Very Low
nMDA receptor 14 5.00 Very Low Very Low Very Low
tolerance 14 5.00 Very Low Very Low Very Low
amygdala 7 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 7 94.00 High High
Adhesions 21 93.00 High High
Alzheimer's Dementia 14 15.72 Low Low
Amyloid Plaque 7 11.04 Low Low
Depression 35 5.00 Very Low Very Low Very Low
Immunization 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin promotes dendrite branching (56, 57), we asked whether phosphorylation at Ser-447 affects this aspect of ?
Phosphorylation (phosphorylation) of Ser-447 in dendrite
1) Confidence 0.01 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0.42
Ser-447 phosphorylation by JNK appears to be correlated with ?
Phosphorylation (phosphorylation) of Ser-447
2) Confidence 0.01 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Abstract Doc Link PMC2667352 Disease Relevance 0.09 Pain Relevance 0
To test whether TTX-induced phosphorylation of Ser-447 is dependent on JNK, we pretreated neurons for 10 min with JNK inhibitor SP600125 (20 ?
Phosphorylation (phosphorylation) of Ser-447 in neurons associated with tetrodotoxin
3) Confidence 0.01 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0.60
More importantly, phosphorylation was confirmed in vivo for a novel phosphorylation site (Ser-447) discovered in ?
Phosphorylation (phosphorylation) of Ser-447
4) Confidence 0.01 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0.09 Pain Relevance 0
These data indicate that JNK is the main mediator of basal Ser-447 phosphorylation in neurons.
Phosphorylation (phosphorylation) of Ser-447 in neurons
5) Confidence 0.01 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0.13
Which kinase is responsible for phosphorylation of Ser-447 in ?
Phosphorylation (phosphorylation) of Ser-447
6) Confidence 0.01 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0
-catenin Ser-447 phosphorylation by TTX and bicuculline is bidirectional and qualitatively similar to that of PSD-95 Ser-295 (55) consistent with both of these sites being targets of JNK MAPK.
Phosphorylation (phosphorylation) of Ser-447 associated with tetrodotoxin
7) Confidence 0.01 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0.49

General Comments

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