INT266570

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.45
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Peripheral nerve 4
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nav1.8 77 100.00 Very High Very High Very High
Kinase C 38 100.00 Very High Very High Very High
c fibre 18 95.04 Very High Very High Very High
substance P 66 93.76 High High
dorsal root ganglion 115 90.80 High High
Pain 19 82.16 Quite High
Peripheral sensitization 1 81.84 Quite High
calcitonin gene related peptide 1 73.40 Quite High
Neuropeptide 2 72.12 Quite High
Sciatic nerve 110 59.92 Quite High
Disease Link Frequency Relevance Heat
Nerve Compression Syndromes 62 99.96 Very High Very High Very High
Injury 80 97.76 Very High Very High Very High
Ganglion Cysts 117 90.80 High High
Pain 17 82.16 Quite High
Inflammatory Pain 3 38.04 Quite Low
Neuropathic Pain 37 36.84 Quite Low
Hyperalgesia 5 36.24 Quite Low
INFLAMMATION 15 31.08 Quite Low
Nociception 11 22.72 Low Low
Nervous System Injury 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with our previous finding that the modulation of TRPV1 by NK-1 receptor was mediated by activation of PLC and downstream PKC pathway [9], the present results also proved the involvement of PKC in the interaction between NK-1 and Nav1.8.
Positive_regulation (involvement) of Nav1.8 Binding (interaction) of associated with kinase c and nav1.8
1) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.21 Pain Relevance 1.47
Peripheral nerve NaV1.8 immunoreactivity after SNE
Positive_regulation (after) of NaV1 Binding (immunoreactivity) of in Peripheral nerve associated with nerve compression syndromes
2) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.62 Pain Relevance 0.36
Peripheral nerve NaV1.8 immunoreactivity after SNE
Positive_regulation (Peripheral nerve) of NaV1 Binding (immunoreactivity) of in Peripheral nerve associated with nerve compression syndromes
3) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.62 Pain Relevance 0.36

General Comments

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