INT266617

Context Info Confidence 0.41 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.28 Pain Relevance 0.03

plasma membrane (GJC1, Tjp1) transport (GJC1) Golgi apparatus (Tjp1) nucleus (Tjp1) cytoplasm (Tjp1)

Anatomy Link Frequency gastric epithelium 1 GJC1 (Homo sapiens) Tjp1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory response 4 51.32 tolerance 1 46.08 Inflammatory mediators 5 26.12 Inflammation 15 5.00 cINOD 1 5.00 ischemia 1 5.00 peptic ulcer disease 1 5.00

Disease Link Frequency Relevance Heat Infection 41 92.28 Adhesions 2 77.84 INFLAMMATION 23 50.96 Gastritis 9 50.00 Apoptosis 8 5.00 Cancer 6 5.00 Sprains And Strains 5 5.00 Stomach Cancer 4 5.00 Adenocarcinoma 3 5.00 Lymphatic System Cancer 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As both connexin 45 and Aqp5 are know to play a role in intercellular transport of water and small molecules, and there is experimental evidence that connexin 45 interacts directly with Tjp1 [58,59], it would appear that Cox-2 also has a role in the maintenance of water balance in the gastric epithelium.

connexin 45 Binding (interacts) of Tjp1 in gastric epithelium

1) Confidence 0.41 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.28 Pain Relevance 0.03

General Comments

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