INT266627

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.54
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Ugt1a2) endoplasmic reticulum (Ugt1a2) enzyme binding (Ugt1a2)
Ugt1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
backache 3 99.76 Very High Very High Very High
Inflammation 128 98.12 Very High Very High Very High
Pain 13 94.56 High High
cytokine 13 93.12 High High
headache 6 87.96 High High
pruritus 3 86.20 High High
Inflammatory response 84 64.56 Quite High
cva 4 50.40 Quite High
metalloproteinase 6 48.56 Quite Low
ischemia 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 3 99.76 Very High Very High Very High
Jaundice 10 99.60 Very High Very High Very High
Infection 10 99.58 Very High Very High Very High
Congenital Anomalies 11 98.26 Very High Very High Very High
INFLAMMATION 210 98.12 Very High Very High Very High
Newborn Jaundice 4 96.56 Very High Very High Very High
Thrombocytopenia 18 96.20 Very High Very High Very High
Hyperbilirubinemia 16 96.08 Very High Very High Very High
Neutropenia 15 95.36 Very High Very High Very High
Pain 11 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other grade 3–4 adverse events included elevation of lipase, bilirubin, and back pain.
Positive_regulation (elevation) of bilirubin associated with backache
1) Confidence 0.04 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.75 Pain Relevance 0.19
Grade 3–4 elevations in bilirubin occurred in 9% and lipase in 18% of patients.
Positive_regulation (elevations) of bilirubin
2) Confidence 0.04 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 1.42 Pain Relevance 0.13
The majority of serum chemistry abnormalities ranged from mild to moderate and included elevations of AST/ALT in 4% of patients and elevations of bilirubin and lipase, occurred in 9% and 14% of patients, respectively.
Positive_regulation (elevations) of bilirubin associated with congenital anomalies
3) Confidence 0.03 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.27 Pain Relevance 0
However, the relation of the biliary pigments to infection is ambivalent since increasing serum levels of biliverdin and bilirubin were shown to be beneficial in the setting of inflammation [69].
Positive_regulation (increasing) of bilirubin associated with inflammation and infection
4) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2667492 Disease Relevance 1.76 Pain Relevance 0.19
Postoperative jaundice is associated with elevated serum bilirubin, mainly conjugated, above 3 mg per dl.
Positive_regulation (elevated) of bilirubin associated with jaundice
5) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2667492 Disease Relevance 1.35 Pain Relevance 0.04

General Comments

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