INT266661

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.86
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (AKT1, BAD) cytosol (AKT1, BAD) cell differentiation (AKT1)
nucleoplasm (AKT1) mitochondrion (BAD) transport (AKT1)
AKT1 (Homo sapiens)
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 15 50.40 Quite High
metalloproteinase 3 50.00 Quite Low
cytokine 2 13.12 Low Low
COX2 1 11.32 Low Low
palliative 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 96 100.00 Very High Very High Very High
Apoptosis 74 99.34 Very High Very High Very High
Cancer 34 96.68 Very High Very High Very High
Fibrosarcoma 1 84.80 Quite High
Malignant Neoplastic Disease 4 83.72 Quite High
Lung Cancer 2 79.36 Quite High
Death 3 75.20 Quite High
INFLAMMATION 17 50.40 Quite High
Adhesions 14 5.00 Very Low Very Low Very Low
Metastasis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated Akt in turn phosphorylates several proteins that regulate cell survival, including Bad and caspase 9 [30].
Akt Regulation (regulate) of Bad
1) Confidence 0.10 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.21 Pain Relevance 0.03
In our study, corresponding with the alteration of Akt, pBad (pS136) was regulated by constitutive and induced FAK phosphorylation in pancreatic cancer cells.
Akt Regulation (regulated) of pBad associated with pancreatic cancer
2) Confidence 0.04 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.89 Pain Relevance 0
Apoptosis-associated proteins Bax, Bcl-2, BAD and survivin have all been demonstrated to be involved in the chemoresistance of pancreatic cancer cells and be regulated by FAK or Akt [29-33].
Akt Regulation (regulated) of BAD associated with pancreatic cancer and apoptosis
3) Confidence 0.01 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.76 Pain Relevance 0

General Comments

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