INT266745

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.53
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ACR) DNA binding (ACR) protein complex (ACR)
Anatomy Link Frequency
joints 4
ACR (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 268 94.12 High High
Adalimumab 545 92.64 High High
methotrexate 111 91.84 High High
Infliximab 24 83.36 Quite High
diclofenac 5 83.20 Quite High
Pain 5 80.64 Quite High
spinal inflammation 62 52.92 Quite High
Arthritis 78 51.12 Quite High
Inflammation 53 5.00 Very Low Very Low Very Low
antagonist 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 81 95.92 Very High Very High Very High
Rheumatoid Arthritis 268 94.12 High High
Pain 5 80.64 Quite High
Low Back Pain 66 52.92 Quite High
Seronegative Spondarthritis 62 51.12 Quite High
Infection 22 39.52 Quite Low
INFLAMMATION 47 5.00 Very Low Very Low Very Low
Arthritis 18 5.00 Very Low Very Low Very Low
Necrosis 14 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACR20, ACR50, and ACR70 response rates
Regulation (response) of Gene_expression (rates) of ACR50
1) Confidence 0.10 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2668560 Disease Relevance 0.16 Pain Relevance 0.41
Fig. 2ACR20, ACR50, and ACR70 response rates over time

ACR core components

Regulation (response) of Gene_expression (rates) of ACR50
2) Confidence 0.10 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2668560 Disease Relevance 0.08 Pain Relevance 0.26
ACR20, ACR50, and ACR70 response rates
Regulation (response) of Gene_expression (rates) of ACR70
3) Confidence 0.10 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2668560 Disease Relevance 0.16 Pain Relevance 0.38
ACR20, ACR50, and ACR70 response rates
Regulation (response) of Gene_expression (rates) of ACR20
4) Confidence 0.10 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2668560 Disease Relevance 0.16 Pain Relevance 0.41
Fig. 2ACR20, ACR50, and ACR70 response rates over time

ACR core components

Regulation (response) of Gene_expression (rates) of ACR70
5) Confidence 0.09 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2668560 Disease Relevance 0.08 Pain Relevance 0.26
Secondary endpoints included ACR50 and ACR70 responses at week 16; improvement in ACR20, ACR50, and ACR70 responses over time; improvement in numeric index of ACR response (ACR-N); improvement in Disease Activity Score using 28 joints (DAS28); and improvement in Health Assessment Questionnaire (HAQ) disability scores.
Regulation (responses) of Gene_expression (improvement) of ACR20 in joints associated with disease
6) Confidence 0.04 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 0.45 Pain Relevance 0.57
Secondary endpoints included ACR50 and ACR70 responses at week 16; improvement in ACR20, ACR50, and ACR70 responses over time; improvement in numeric index of ACR response (ACR-N); improvement in Disease Activity Score using 28 joints (DAS28); and improvement in Health Assessment Questionnaire (HAQ) disability scores.
Regulation (responses) of Gene_expression (improvement) of ACR50 in joints associated with disease
7) Confidence 0.04 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 0.45 Pain Relevance 0.57

General Comments

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