INT266764

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.55
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TPSD1, SFTPA1) extracellular space (SFTPA1) peptidase activity (TPSD1)
Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
mast cell 3
TPSD1 (Homo sapiens)
F2RL1 (Homo sapiens)
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 44 100.00 Very High Very High Very High
substance P 21 100.00 Very High Very High Very High
endometriosis 168 98.92 Very High Very High Very High
Pain 16 98.24 Very High Very High Very High
Nerve growth factor 16 96.36 Very High Very High Very High
Neuropeptide 3 91.44 High High
cytokine 27 89.72 High High
Peripheral nervous system 1 66.28 Quite High
Neurotransmitter 2 64.48 Quite High
Catecholamine 8 58.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 44 100.00 Very High Very High Very High
Endometriosis 224 98.92 Very High Very High Very High
Pain 17 98.24 Very High Very High Very High
Neurogenic Inflammation 1 88.12 High High
Stress 34 68.48 Quite High
Anxiety Disorder 2 66.96 Quite High
Lymphocytosis 1 37.12 Quite Low
Reprotox - General 3 21 6.32 Low Low
Disease 24 5.00 Very Low Very Low Very Low
Adhesions 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the activation of PAR-2 on afferent neurons, e.g., by proteases such as mast cell tryptase, leads to subsequent release of pro-inflammatory CGRP and SP [169], which might provide explanation for pain during inflammation.
tryptase Positive_regulation (activation) of PAR-2 in mast cell Positive_regulation (leads) of Localization (release) of SP in mast cell associated with pain, inflammation and substance p
1) Confidence 0.00 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.55 Pain Relevance 1.76

General Comments

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