INT26677

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Context Info
Confidence 0.50
First Reported 1983
Last Reported 1989
Negated 2
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk, Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
stomach 4
Penk (Rattus norvegicus)
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 10 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
Morphine 2 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
Opioid 8 92.32 High High
Neurotransmitter 2 89.80 High High
opiate 5 88.96 High High
narcan 8 75.04 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both met-enkephalin and beta-endorphin stimulated the release of VIP significantly whilst not affecting the release of TRH.
enkephalin Neg (not) Regulation (affecting) of Localization (release) of TRH associated with enkephalin
1) Confidence 0.50 Published 1987 Journal Life Sci. Section Abstract Doc Link 3102870 Disease Relevance 0 Pain Relevance 0.57
The effect of morphine and leucine enkephalin on basal and K+-induced TRH release by superfused mediobasal hypothalami in rats was investigated in an oxygenated modified Locke medium at 37 degrees C during 10 min.
enkephalin Spec (investigated) Regulation (effect) of Localization (release) of TRH associated with enkephalin and morphine
2) Confidence 0.30 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6412152 Disease Relevance 0 Pain Relevance 0.76
The effect of endogenous opioid peptides (beta-endorphin, leucine-enkephalin, dynorphin 1-13 on the release of thyrotropin releasing hormone (TRH) from the rat stomach in vitro was studied.
leucine-enkephalin Regulation (effect) of Localization (release) of TRH in stomach associated with dynorphin, endogenous opioid and enkephalin
3) Confidence 0.10 Published 1989 Journal Endocrinol. Exp. Section Abstract Doc Link 2565806 Disease Relevance 0 Pain Relevance 0.58
The effect of endogenous opioid peptides (beta-endorphin, leucine-enkephalin, dynorphin 1-13 on the release of thyrotropin releasing hormone (TRH) from the rat stomach in vitro was studied.
leucine-enkephalin Regulation (effect) of Localization (release) of thyrotropin releasing hormone in stomach associated with dynorphin, endogenous opioid and enkephalin
4) Confidence 0.10 Published 1989 Journal Endocrinol. Exp. Section Abstract Doc Link 2565806 Disease Relevance 0 Pain Relevance 0.58
In addition, leu-enkephalin was found to have no effect on the release of either VIP or TRH.
leu-enkephalin Neg (no) Regulation (effect) of Localization (release) of TRH associated with enkephalin
5) Confidence 0.08 Published 1987 Journal Life Sci. Section Abstract Doc Link 3102870 Disease Relevance 0 Pain Relevance 0.56

General Comments

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